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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error


Fan, Q and Verhoeven, VJM and Wojciechowski, R and Barathi, VA and Hysi, PG and Guggenheim, JA and Hohn, R and Vitart, V and Khawaja, AP and Yamashiro, K and Hosseini, SM and Lehtimaki, T and Lu, Y and Haller, T and Xie, J and Delcourt, C and Pirastu, M and Wedenoja, J and Gharahkhani, P and Venturini, C and Miyake, M and Hewitt, AW and Guo, X and Mazur, J and Huffman, JE and Williams, KM and Polasek, O and Campbell, H and Rudan, I and Vatavuk, Z and Wilson, JF and Joshi, PK and McMahon, G and St Pourcain, B and Evans, DM and Simpson, CL and Schwantes-An, T-H and Igo, RP and Mirshahi, A and Cougnard-Gregoire, A and Bellenguez, C and Blettner, M and Raitakari, O and Kahonen, M and Seppala, I and Zeller, T and Meitinger, T and Ried, JS and Gieger, C and Portas, L and Van Leeuwen, EM and Amin, N and Uitterlinden, AG and Rivadeneira, F and Hofman, A and Vingerling, JR and Wang, YX and Wang, X and Tai-Hui Boh, E and Ikram, MK and Sabanayagam, C and Gupta, P and Tan, V and Zhou, L and Ho, CEH and Lim, W and Beuerman, RW and Siantar, R and Tai, E-S and Vithana, E and Mihailov, E and Khor, C-C and Hayward, C and Luben, RN and Foster, PJ and Klein, BEK and Klein, R and Wong, H-S and Mitchell, P and Metspalu, A and Aung, T and Young, TL and He, M and Parssinen, O and van Duijn, CM and Wang, JJ and Williams, C and Jonas, JB and Teo, Y-Y and Mackey, DA and Oexle, K and Yoshimura, N and Paterson, AD and Pfeiffer, N and Wong, T-Y and Baird, PN and Stambolian, D and Bailey-Wilson, JE and Cheng, C-Y and Hammond, CJ and Klaver, CCW and Saw, S-M, Consortium for Refractive Error and Myopia (CREAM), Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error, Nature Communications, 7 Article 11008. ISSN 2041-1723 (2016) [Refereed Article]


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Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.1038/ncomms11008


Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP x education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P <8.5 x 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
UTAS Author:Mackey, DA (Professor David Mackey)
ID Code:111321
Year Published:2016
Web of Science® Times Cited:75
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-09-08
Last Modified:2022-08-26
Downloads:136 View Download Statistics

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