eCite Digital Repository

Plasma concentrations of midazolam during continuous subcutaneous administration in palliative care

Citation

Bleasel, MD and Peterson, GM and Dunne, PF, Plasma concentrations of midazolam during continuous subcutaneous administration in palliative care, Palliative Medicine: A Multiprofessional Journal, 8, (3) pp. 231-6. ISSN 0269-2163 (1994) [Refereed Article]

DOI: doi:10.1177/026921639400800307

Abstract

We have investigated the steady-state plasma concentrations of midazolam during continuous subcutaneous administration in palliative care. Using a sensitive gas chromatography with electron capture detector assay, plasma concentrations of midazolam were measured in 11 patients (median age 68 years; range 47-82 years; six females) receiving the drug by continuous subcutaneous infusion (median rate 20 mg/day; range 10-60 mg/day). While not significant, the infusion rate tended to decrease with increasing age of the patient (Spearman's p = -0.51; p = 0.11). The steady-state plasma concentration range was 10-147 ng/ml, with a median of 30 ng/ml. Infusion rates and plasma concentrations of midazolam were correlated (Spearman's p = 0.71; p < 0.05). No other significant relationships were found between plasma concentrations and the variables of age, sex and liver function.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Clinical Pharmacology and Therapeutics
Objective Division:Health
Objective Group:Health and Support Services
Objective Field:Palliative Care
Author:Bleasel, MD (Dr Martin Bleasel)
Author:Peterson, GM (Professor Gregory Peterson)
Author:Dunne, PF (Associate Professor Paul Dunne)
ID Code:111296
Year Published:1994
Deposited By:Faculty Office Health
Deposited On:2016-09-07
Last Modified:2016-09-07
Downloads:0

Repository Staff Only: item control page