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Stability of midazolam in sodium chloride infusion packs


Blaesel, MD and Peterson, GM and Jestrimski, JW and Kerry, W, Stability of midazolam in sodium chloride infusion packs, Journal of Pharmacy Practice and Research, 23, (4) pp. 260-262. ISSN 1445-937X (1993) [Refereed Article]


Objective: To determine the stability of midazolam in an intravenous infusion solution. Study Procedure: The physicochemical stability of midazolam (1 mg/mL) in sodium chloride 0.9% for injection in 100 mL polyvinyl chloride infusion bags was studied. Solutions were stored for 49 days at 4 degree C, 2.0 degree C protected from light and 20 degree C with fluorescent lighting for 12 hours each 24 hours, and the concentration of midazolam was periodically determined using a high performance liquid chromatography assay.

Results: The midazolam solutions were relatively stable, with all solutions maintaining over 90% of their initial concentration for the duration of the study. Differences in the loss of midazolam between the storage conditions were not statistically significant.

Conclusions: The clinical implication of these results is that, on the basis of physicochemical stability, infusion bags of midazolam in sodium chloride 0.9% can be safely prepared and stored at or below 20 degree C for periods of approximately one month.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Provision of health and support services
Objective Field:Allied health therapies (excl. mental health services)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Jestrimski, JW (Mr James Jestrimski)
ID Code:111198
Year Published:1993
Deposited By:College Office - CHM
Deposited On:2016-09-02
Last Modified:2016-09-02

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