Blaesel, MD and Peterson, GM and Jestrimski, JW and Kerry, W, Stability of midazolam in sodium chloride infusion packs, Journal of Pharmacy Practice and Research, 23, (4) pp. 260-262. ISSN 1445-937X (1993) [Refereed Article]
Objective: To determine the stability of midazolam in an intravenous infusion solution. Study Procedure: The physicochemical stability of midazolam (1 mg/mL) in sodium chloride 0.9% for injection in 100 mL polyvinyl chloride infusion bags was studied. Solutions were stored for 49 days at 4 degree C, 2.0 degree C protected from light and 20 degree C with fluorescent lighting for 12 hours each 24 hours, and the concentration of midazolam was periodically determined using a high performance liquid chromatography assay.
Results: The midazolam solutions were relatively stable, with all solutions maintaining over 90% of their initial concentration for the duration of the study. Differences in the loss of midazolam between the storage conditions were not statistically significant.
Conclusions: The clinical implication of these results is that, on the basis of physicochemical stability, infusion bags of midazolam in sodium chloride 0.9% can be safely prepared and stored at or below 20 degree C for periods of approximately one month.
|Item Type:||Refereed Article|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Pharmacology and pharmaceutical sciences|
|Research Field:||Clinical pharmacology and therapeutics|
|Objective Group:||Provision of health and support services|
|Objective Field:||Allied health therapies (excl. mental health services)|
|UTAS Author:||Peterson, GM (Professor Gregory Peterson)|
|UTAS Author:||Jestrimski, JW (Mr James Jestrimski)|
|Deposited By:||College Office - CHM|
Repository Staff Only: item control page