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Stability of midazolam in sodium chloride infusion packs
Citation
Blaesel, MD and Peterson, GM and Jestrimski, JW and Kerry, W, Stability of midazolam in sodium chloride infusion packs, Journal of Pharmacy Practice and Research, 23, (4) pp. 260-262. ISSN 1445-937X (1993) [Refereed Article]
Abstract
Objective: To determine the stability of midazolam in an intravenous infusion solution. Study Procedure: The physicochemical stability of midazolam (1 mg/mL) in sodium chloride 0.9% for injection in 100 mL polyvinyl chloride infusion bags was studied. Solutions were stored for 49 days at 4 degree C, 2.0 degree C protected from light and 20 degree C with fluorescent lighting for 12 hours each 24 hours, and the concentration of midazolam was periodically determined using a high performance liquid chromatography assay.
Results: The midazolam solutions were relatively stable, with all solutions maintaining over 90% of their initial concentration for the duration of the study. Differences in the loss of midazolam between the storage conditions were not statistically significant.
Conclusions: The clinical implication of these results is that, on the basis of physicochemical stability, infusion bags of midazolam in sodium chloride 0.9% can be safely prepared and stored at or below 20 degree C for periods of approximately one month.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Pharmacology and pharmaceutical sciences |
Research Field: | Clinical pharmacology and therapeutics |
Objective Division: | Health |
Objective Group: | Provision of health and support services |
Objective Field: | Allied health therapies (excl. mental health services) |
UTAS Author: | Peterson, GM (Professor Gregory Peterson) |
UTAS Author: | Jestrimski, JW (Mr James Jestrimski) |
ID Code: | 111198 |
Year Published: | 1993 |
Deposited By: | College Office - CHM |
Deposited On: | 2016-09-02 |
Last Modified: | 2016-09-02 |
Downloads: | 0 |
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