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Baclofen does plasma level monitoring have a clinical role


Peterson, GM and McLean, SR and Millingen, KS, Baclofen does plasma level monitoring have a clinical role, Journal of Pharmacy Practice and Research, 21, (1) pp. 20-24. ISSN 1445-937X (1991) [Refereed Article]


Patients vary considerably in their dosage requirements of the muscle relaxant drug, baclofen. A study was therefore performed to determine whether plasma level monitoring of baclofen would assist in the individualization of its dosage. Maintenance dosages, steady-state peak and trough plasma concentrations of baclofen, and clinical response were examined in 13 patients with varying degrees of muscle spasticity. Peak plasma concentrations of baclofen and clinical response were significantly related, but the relationship was weaker than that observed between daily dosage and clinical response. It can be concluded that plasma level monitoring would have only a limited clinical role in ascertaining whether baclofen dosage is adequate.sbd.most patients will require a dosage of at least 50 daily, resulting in steady-state plasma concentrations above 250 ng/mL (peak) and 50 ng/mL (trough).

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Provision of health and support services
Objective Field:Allied health therapies (excl. mental health services)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:McLean, SR (Professor Stuart McLean)
ID Code:111194
Year Published:1991
Deposited By:College Office - CHM
Deposited On:2016-09-02
Last Modified:2016-09-02

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