Saito, M and Khan, F and Stoklosa, T and Iannaccone, A and Negishi, K and Marwick, TH, Prognostic Implications of LV Strain Risk Score in Asymptomatic Patients With Hypertensive Heart Disease, JACC: Cardiovascular Imaging, 9, (8) pp. 911-921. ISSN 1936-878X (2016) [Refereed Article]
Copyright 2016 by the American College of Cardiology Foundation
BACKGROUND: In patients with hypertensive heart disease, MACE are associated with abnormal LV morphology, but their association with subclinical LV dysfunction is unclear.
METHODS: We retrospectively studied 388 asymptomatic nonischemic patients with hypertension who had abnormal LV geometry at a baseline echocardiogram between 2005 and 2014. Global longitudinal strain (GLS) was measured using speckle tracking. Patients were followed for MACE (death and admission because of heart failure, myocardial infarction, and strokes) over median of 4 years. A Cox proportional hazards model was used to assess the association of parameters with MACE.
RESULTS: MACE (n = 72; 19%) were associated with higher prevalence of concentric hypertrophy and impaired GLS (both, p < 0.01). The association of GLS with MACE was independent of and incremental to clinical parameters and concentric hypertrophy. Echocardiographic follow-up was performed in 55 patients (median duration, 3 years); deterioration in GLS was also associated with the 10 patients experiencing MACE after the second echo. A risk score was developed using age >70, atrial fibrillation, concentric hypertrophy, and baseline GLS >-16% from the derivation cohort (C statistic, 0.71), and a separate validation cohort showed it to have good discrimination for MACE (C statistic, 0.71).
CONCLUSIONS: GLS and its deterioration are associated with MACE in asymptomatic hypertensive heart disease. A risk score incorporating strain was useful for predicting risk of MACE.
|Item Type:||Refereed Article|
|Keywords:||MACE, hypertensive heart disease, left ventricular mass, risk score, strain|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Saito, M (Dr Makoto Saito)|
|Author:||Iannaccone, A (Dr Andrea Iannaccone)|
|Author:||Negishi, K (Dr Kazuaki Negishi)|
|Author:||Marwick, TH (Professor Tom Marwick)|
|Web of Science® Times Cited:||11|
|Deposited By:||Menzies Institute for Medical Research|
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