Wang, K and Xu, J and Cai, J and Zheng, S and Han, W and Antony, B and Ding, C, Serum Levels of Interleukin-17 and Adiponectin Are Associated with Infrapatellar Fat Pad Volume and Signal Intensity Alternation in Patients with Knee Osteoarthritis, Arthritis Research & Therapy, 18, (1) Article 193. ISSN 1478-6362 (2016) [Refereed Article]
Copyright the Authors. Licenced under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
METHODS: A total of 170 subjects with symptomatic knee OA (mean age 55.4 years, range 34-74, 88.2 % females) were included. IPFP volume was measured on T1-weighted spoiled gradient-recalled acquisition in the steady state images and was computed by using a software program. IPFP high signal intensity (grades 0-3) was assessed on T2-weighted fast spin echo images. Serum IL-17, adiponectin, and resistin levels were measured using an enzyme-linked immunosorbent assay.
RESULTS: In multivariable analyses, serum IL-17 was negatively associated with IPFP volume (β = -0.185, 95 % CI -0.337 to -0.034) but positively associated with the severity of IPFP signal intensity alteration (OR 1.23, 95 % CI 1.06-1.42) after adjustment for age, sex, weight, and height. Serum adiponectin was positively associated with IPFP volume (β = 0.016, 95 % CI 0.001-0.032) but negatively associated with IPFP signal intensity alteration (OR 0.99, 95 % CI 0.98-1.00) after adjustment for covariates. Resistin was positively associated with IPFP signal intensity alteration (OR 1.13, 95 % CI 1.04-1.23) but not with IPFP volume. The significant associations of adiponectin or resistin disappeared after further adjustment for IL-17; in contrast, the significant associations of IL-17 remained after further adjustment for adiponectin.
CONCLUSIONS: While serum IL-17 and resistin were associated with reduced IPFP volume and/or increased abnormal signal intensity alteration, serum adiponectin had opposite associations that were largely through IL-17. These findings suggest that serum adipocytokines may have a role to play in IPFP changes of knee OA.
|Item Type:||Refereed Article|
|Keywords:||Adipokines, Cartilage, Cytokines, Epidemiology, Infrapatellar fat pad, Osteoarthritis|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Rheumatology and arthritis|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Han, W (Dr Weiyu Han)|
|UTAS Author:||Antony, B (Dr Benny Eathakkattu Antony)|
|UTAS Author:||Ding, C (Professor Chang-Hai Ding)|
|Web of Science® Times Cited:||17|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||154 View Download Statistics|
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