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Serum Levels of Interleukin-17 and Adiponectin Are Associated with Infrapatellar Fat Pad Volume and Signal Intensity Alternation in Patients with Knee Osteoarthritis

Citation

Wang, K and Xu, J and Cai, J and Zheng, S and Han, W and Antony, B and Ding, C, Serum Levels of Interleukin-17 and Adiponectin Are Associated with Infrapatellar Fat Pad Volume and Signal Intensity Alternation in Patients with Knee Osteoarthritis, Arthritis Research & Therapy, 18, (1) Article 193. ISSN 1478-6362 (2016) [Refereed Article]


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Copyright the Authors. Licenced under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1186/s13075-016-1088-9

Abstract

BACKGROUND: In the present study, we sought to generate hypotheses regarding the associations of serum levels of interleukin (IL)-17, adiponectin, and resistin with magnetic resonance imaging-measured infrapatellar fat pad (IPFP) size and signal intensity alterations in patients with knee osteoarthritis (OA).

METHODS: A total of 170 subjects with symptomatic knee OA (mean age 55.4 years, range 34-74, 88.2 % females) were included. IPFP volume was measured on T1-weighted spoiled gradient-recalled acquisition in the steady state images and was computed by using a software program. IPFP high signal intensity (grades 0-3) was assessed on T2-weighted fast spin echo images. Serum IL-17, adiponectin, and resistin levels were measured using an enzyme-linked immunosorbent assay.

RESULTS: In multivariable analyses, serum IL-17 was negatively associated with IPFP volume (β = -0.185, 95 % CI -0.337 to -0.034) but positively associated with the severity of IPFP signal intensity alteration (OR 1.23, 95 % CI 1.06-1.42) after adjustment for age, sex, weight, and height. Serum adiponectin was positively associated with IPFP volume (β = 0.016, 95 % CI 0.001-0.032) but negatively associated with IPFP signal intensity alteration (OR 0.99, 95 % CI 0.98-1.00) after adjustment for covariates. Resistin was positively associated with IPFP signal intensity alteration (OR 1.13, 95 % CI 1.04-1.23) but not with IPFP volume. The significant associations of adiponectin or resistin disappeared after further adjustment for IL-17; in contrast, the significant associations of IL-17 remained after further adjustment for adiponectin.

CONCLUSIONS: While serum IL-17 and resistin were associated with reduced IPFP volume and/or increased abnormal signal intensity alteration, serum adiponectin had opposite associations that were largely through IL-17. These findings suggest that serum adipocytokines may have a role to play in IPFP changes of knee OA.

Item Details

Item Type:Refereed Article
Keywords:Adipokines, Cartilage, Cytokines, Epidemiology, Infrapatellar fat pad, Osteoarthritis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Han, W (Dr Weiyu Han)
Author:Antony, B (Dr Benny Eathakkattu Antony)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:111153
Year Published:2016
Web of Science® Times Cited:5
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-09-01
Last Modified:2017-11-01
Downloads:52 View Download Statistics

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