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A preliminary study of the stability of midazolam in polypropylene syringes

Citation

Peterson, GM and Khoo, BHC and Galloway, JG and Paterson, J, A preliminary study of the stability of midazolam in polypropylene syringes, Australian Journal of Hospital Pharmacy, 21, (2) pp. 115-118. ISSN 0310-6810 (1991) [Refereed Article]

Abstract

The physiochemical stability of midazolam stored in polypyropylene syringes was studied. Solutions containing approximately 3 mg/mL of midazolam were prepared by diluting commercial ampoules of the drug with sodium chloride 0.9% for injection. The solutions were stored at 20.degree.C, 32.degree.C (to simulate usage conditions), and 60.degree.C for 13 days, and the concentration of midazolam was periodically determined using a high performance liquid chromatography assay. The midazolam solutions were reasonably stable, with all solutions maintaining over 90% of their initial chemical potency for at least one week. There were no evident changes in the physical appearance or pH values of the solutions over the couse of the study. The presence of morphine tartrate seemed to slow the degradation of midazolam, possibly by increasing the pH of the solution. There was no significant uptake of midazolam into the syringe. The clinical implication of these results is that, on the basis of physicocochemical stability, syringes of midazolam (with or without morphine) need only be changed at intervals of up to one week in palliative care patients receiving the drug via a portable subcutaneous infusion device.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Pharmaceutical Sciences
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Peterson, GM (Professor Gregory Peterson)
Author:Galloway, JG (Mr Jim Galloway)
ID Code:111140
Year Published:1991
Deposited By:Faculty Office Health
Deposited On:2016-08-31
Last Modified:2016-08-31
Downloads:0

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