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Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy

Citation

Peterson, GM and Boyle, RR and Francis, HW and Oliver, NW and Paterson, J and von Witt, RJ and Taylor, GR, Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy, European journal of clinical pharmacology, 39, (4) pp. 419-21. ISSN 0031-6970 (1990) [Refereed Article]

DOI: doi:10.1007/BF00315424

Abstract

This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were receiving excessive dosages of allopurinol. Consequently, the plasma oxipurinol concentrations were often very high (mean (SD) was 156 (109) mumol.l-1). Accumulation of oxipurinol was inversely related to renal function. Plasma concentrations of oxipurinol and urate were not significantly related. However, most patients with oxipurinol concentrations of up to 100 mumol.l-1 had urate concentrations within the normal reference range.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Clinical Pharmacology and Therapeutics
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Peterson, GM (Professor Gregory Peterson)
Author:Boyle, RR (Dr Rebecca Boyle)
Author:Francis, HW (Dr Hilton Francis)
Author:von Witt, RJ (Dr Richard von Witt)
Author:Taylor, GR (Mr George Taylor)
ID Code:111103
Year Published:1990
Web of Science® Times Cited:35
Deposited By:Faculty Office Health
Deposited On:2016-08-31
Last Modified:2016-08-31
Downloads:0

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