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Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy
journal contribution
posted on 2023-05-18, 21:55 authored by Gregory PetersonGregory Peterson, Boyle, RR, Francis, HW, Oliver, NW, Paterson, J, von Witt, RJ, George TaylorGeorge TaylorThis study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were receiving excessive dosages of allopurinol. Consequently, the plasma oxipurinol concentrations were often very high (mean (SD) was 156 (109) mumol.l-1). Accumulation of oxipurinol was inversely related to renal function. Plasma concentrations of oxipurinol and urate were not significantly related. However, most patients with oxipurinol concentrations of up to 100 mumol.l-1 had urate concentrations within the normal reference range.
History
Publication title
European journal of clinical pharmacologyVolume
39Issue
4Pagination
419-21ISSN
0031-6970Department/School
College Office - College of Health and MedicinePublisher
Springer-VerlagPlace of publication
United StatesRepository Status
- Restricted