eCite Digital Repository

Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy


Peterson, GM and Boyle, RR and Francis, HW and Oliver, NW and Paterson, J and von Witt, RJ and Taylor, GR, Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy, European journal of clinical pharmacology, 39, (4) pp. 419-21. ISSN 0031-6970 (1990) [Refereed Article]

DOI: doi:10.1007/BF00315424


This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were receiving excessive dosages of allopurinol. Consequently, the plasma oxipurinol concentrations were often very high (mean (SD) was 156 (109) mumol.l-1). Accumulation of oxipurinol was inversely related to renal function. Plasma concentrations of oxipurinol and urate were not significantly related. However, most patients with oxipurinol concentrations of up to 100 mumol.l-1 had urate concentrations within the normal reference range.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Boyle, RR (Dr Rebecca Boyle)
UTAS Author:Francis, HW (Dr Hilton Francis)
UTAS Author:von Witt, RJ (Dr Richard von Witt)
UTAS Author:Taylor, GR (Mr George Taylor)
ID Code:111103
Year Published:1990
Web of Science® Times Cited:38
Deposited By:College Office - CHM
Deposited On:2016-08-31
Last Modified:2016-08-31

Repository Staff Only: item control page