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Food does not affect the bioavailability of baclofen


Peterson, GM and McLean, S and Millingen, KS, Food does not affect the bioavailability of baclofen, The Medical journal of Australia, 142, (13) pp. 689-90. ISSN 0025-729X (1985) [Refereed Article]

DOI: doi:10.5694/j.1326-5377.1985.tb113595.x


It is recommended that baclofen, a centrally acting muscle relaxant, be administered with food or milk to minimize its gastrointestinal side-effects. However, there are no published data on the influence of food on the bioavailability of the drug. The extent and rate of absorption of baclofen were investigated after the oral administration of single 20-mg doses to five healthy volunteers. The drug was administered either under fasting conditions or with a standard meal, according to a crossover design. Food did not significantly influence either the rate or the relative extent of absorption of baclofen. Therefore, it is unlikely that the administration of baclofen with food to reduce the likelihood of gastrointestinal toxicity will adversely affect the clinical response to the drug.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:McLean, S (Professor Stuart McLean)
ID Code:111096
Year Published:1985
Web of Science® Times Cited:11
Deposited By:College Office - CHM
Deposited On:2016-08-30
Last Modified:2016-08-30

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