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Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum
Citation
Rahman, AA and Robinson, AM and Brookes, SJH and Eri, R and Nurgali, K, Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum, Cell and tissue research, 366, (2) pp. 285-299. ISSN 0302-766X (2016) [Refereed Article]
Copyright Statement
Copyright Springer-Verlag Berlin Heidelberg 2016
DOI: doi:10.1007/s00441-016-2465-z
Abstract
Rectal prolapse is associated with diminished anal
sensitivity and rectal motor activity. Both sensory and motor
functions are controlled by the extrinsic and intrinsic (enteric
nervous system) innervation of the gastrointestinal tract.
Studies of changes in intestinal innervation in humans and in
animal models with rectal prolapse are extremely scarce. The
Winnie mouse model of spontaneous chronic colitis closely
represents human inflammatory bowel disease and is prone
to develop rectal prolapse. We have investigated changes in
the myenteric and inhibitory motor neurons and evaluated
changes in the density of sensory afferent, sympathetic, and
parasympathetic fibers in the rectal colon of Winnie mice with
and without rectal prolapse. Our results demonstrate that rectal
prolapse in Winnie mice with chronic colitis is correlated with
enhanced levels of inflammation, gross morphological damage,
and muscular hypertrophy of the rectum. Animals with
prolapse have more severe damage to the rectal innervation
compared with Winnie mice without prolapse. This includes
more severe neuronal loss in the myenteric plexus, involving a
decrease in nNOS-immunoreactive neurons (not observed in
Winnie mice without prolapse) and a more pronounced loss of
VAChT-immunoreactive fibers. Both Winnie mice with and
without prolapse have comparable levels of noradrenergic
and sensory fiber loss in the rectum. This is the first study
providing evidence that the damage and death of enteric neurons,
including nitrergic neurons in myenteric ganglia and the
loss of cholinergic nerve fibers, are important factors in structural
changes in the rectum of mice with rectal prolapse.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Rectal prolapse, Enteric neurons, Spontaneous chronic colitis, Winnie mice, Rectum innervation |
| Research Division: | Biological Sciences |
| Research Group: | Genetics |
| Research Field: | Genetic Immunology |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Digestive System Disorders |
| Author: | Eri, R (Dr Raj Eri) |
| ID Code: | 111073 |
| Year Published: | 2016 |
| Web of Science® Times Cited: | 2 |
| Deposited By: | Health Sciences |
| Deposited On: | 2016-08-29 |
| Last Modified: | 2017-03-27 |
| Downloads: | 0 |
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