Berk, M and Woods, RL and Nelson, MR and Shah, RC and Reid, CM and Storey, E and Fitzgerald, SM and Lockery, JE and Wolfe, R and Mohebbi, M and Murray, AM and Kirpach, B and Grimm, R and McNeil, JJ, on behalf of the ASPREE investigators, ASPREE-D: Aspirin for the prevention of depression in the elderly, International Psychogeriatrics, 28, (10) pp. 1741-1748. ISSN 1041-6102 (2016) [Refereed Article]
Copyright 2016 International Psychogeriatric Association
Background: Not only is depression associated with increased inflammation but inflammation is a risk factor for the genesis of depression. Many of the environmental risk factors for depression are transduced through inflammatory signaling. Anti-inflammatory agents show promise for the management of depression in preclinical, epidemiological, and early clinical studies. This opens the door to the potential for anti-inflammatory agents to treat and prevent depression. There are no evidence-based pharmacotherapies for depression prevention.
Method: ASPREE-D, aspirin in the prevention of depression in the elderly, is a sub study of ASPREE, which explores the potential of aspirin to prevent a range of inflammation related disorders in the elderly. With a sample size of 19,114, and a duration of 5 years, this placebo controlled study will be one of the largest randomized controlled trials in psychiatry and will provide definitive evidence on the ability of aspirin to prevent depression.
Results: This paper presents the rationale for the study and presents a summary of the study design.
Conclusions: ASPREE-D may not only define novel therapy but will provide mechanistic proof of concept of the role of inflammation in depression.
|Item Type:||Refereed Article|
|Keywords:||immunology, antidepressants, biomarkers, aspirin, inflammation, risk, prevention, depression|
|Research Division:||Health Sciences|
|Research Group:||Health services and systems|
|Research Field:||Primary health care|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Mental health|
|UTAS Author:||Nelson, MR (Professor Mark Nelson)|
|Funding Support:||National Health and Medical Research Council (APP1081901)|
|Web of Science® Times Cited:||13|
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