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The relationship between meniscal pathology and osteoarthritis depends on the type of meniscal damage visible on magnetic resonance images: data from the Osteoarthritis Initiative

Citation

Antony, B and Driban, JB and Price, LL and Lo, GH and Ward, RJ and Nevitt, M and Lynch, J and Eaton, CB and Ding, C and McAlindon, TE, The relationship between meniscal pathology and osteoarthritis depends on the type of meniscal damage visible on magnetic resonance images: data from the Osteoarthritis Initiative, Osteoarthritis and Cartilage, 25, (1) pp. 76-84. ISSN 1063-4584 (2017) [Refereed Article]

Copyright Statement

Copyright 2016 Osteoarthritis Research Society International

DOI: doi:10.1016/j.joca.2016.08.004

Abstract

OBJECTIVE: To determine the association of different types of meniscal pathology with common measures of osteoarthritis severity and progression: knee pain, bone marrow lesion (BML) volume, and end-stage knee osteoarthritis (esKOA).

DESIGN: Participants were selected from an ancillary project to the Osteoarthritis Initiative (OAI) who had at least one knee with symptomatic osteoarthritis. Baseline magnetic resonance images (MRI) were evaluated for meniscal pathology using a modified International Society of Arthroscopy, Knee Surgery, and Orthopaedic Sports Medicine (ISAKOS) classification system. We collapsed 10 types of meniscal pathology into 5 categories: normal, intrameniscal signal, morphological deformity/extrusion (altered meniscal shape and/or extrusion but no apparent substance loss), tear, and maceration. Outcomes included WOMAC knee pain and BML volume at baseline and after 2-years. We defined the prevalence of esKOA based on a validated algorithm. We performed logistic regression and adjusted for age, sex, and body mass index (BMI).

RESULTS: The 463 participants (53% male) included in the analysis had mean age 63 (9.2) years, BMI 29.6 (4.6) kg/m2, and 71% had Kellgren-Lawrence grade≥2. Morphological deformity/extrusion and maceration, but no other types of meniscal pathology, were associated with BML volume (morphological deformity/extrusion odds ratio [OR]=2.47,95%CI:1.49,4.09, maceration OR=5.85,95%CI:3.40,10.06) and change in BML volume (morphological deformity/extrusion OR=2.17,95%CI:1.37,3.45, maceration OR=3.12,95%CI:1.87,5.19). Only maceration was associated with baseline WOMAC knee pain (OR=2.82,95%CI:1.79,4.43) and prevalence of esKOA (OR=7.53,95%CI:4.25,13.31).

CONCLUSIONS: Based on MRI, morphologic deformity/extrusion and maceration rather than intrameniscal signal or tear were associated with osteoarthritis severity and progression, which highlights the importance of differentiating distinct types of meniscal pathology.

Item Details

Item Type:Refereed Article
Keywords:Meniscus, bone marrow lesions, end-stage knee osteoarthritis, knee pain, tear
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Antony, B (Mr Benny Eathakkattu Antony)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:110920
Year Published:2017
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-08-23
Last Modified:2017-11-20
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