Ramos, JS and Ramos, MV and Dalleck, LC and Borrani, F and Walker, KB and Fassett, RG and Sharman, JE and Coombes, JS, Fitness Is Independently Associated with Central Hemodynamics in Metabolic Syndrome, Medicine and Science in Sports and Exercise, 48, (8) pp. 1539-1547. ISSN 0195-9131 (2016) [Refereed Article]
Copyright 2016 American College of Sports Medicine
METHODS: Sixty-eight individuals with MetS participated in this cross-sectional study. Central hemodynamics is calculated from radial applanation tonometry and comprised aortic reservoir pressure, backward pressure wave (Pb), reflection magnitude (RM), and augmentation index at 75 bpm (AIx75). Cardiorespiratory fitness (CRF) and body fat percentage (BF%) were determined via indirect calorimetry during maximal exercise testing and dual-energy x-ray absorptiometry, respectively.
RESULTS: CRF was inversely associated with aortic reservoir pressure (r = -0.29, P = 0.02), Pb (r = -0.42, P < 0.001), RM (r = -0.48, P < 0.001), and AIx75 (r = -0.65, P < 0.001). BF% was also correlated with AIx75 (r = 0.37, P < 0.05) and RM (r = 0.36, P < 0.005) but at a weaker association compared with CRF. Multiple regression analysis revealed CRF as a predictor of aortic reservoir pressure (β = -0.52, P = <0.01), Pb (β = -0.41, P < 0.03), and AIx75 (β = -0.45, P = 0.01), independent of BF% and other confounding factors.
CONCLUSIONS: CRF predicts central hemodynamics independent of BF% and other confounding factors. This suggests that CRF improvement may be a higher priority when compared with fat loss for lowering the risk of cardiovascular mortality in MetS individuals.
|Item Type:||Refereed Article|
|Keywords:||VO2peak, Obesity, Aortic reservoir function, arterial stiffness, arterioventricular coupling|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Sharman, JE (Professor James Sharman)|
|Web of Science® Times Cited:||6|
|Deposited By:||Menzies Institute for Medical Research|
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