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Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma

Citation

Maikawa, CL and Weichenthal, S and Wheeler, AJ and Dobbin, NA and Smargiassi, A and Evans, G and Liu, L and Goldberg, MS and Pollitt, KJG, Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma, Environmental Health Perspectives, 124, (10) pp. 1616-1622. ISSN 0091-6765 (2016) [Refereed Article]


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Copyright Statement

Public domain 'Reproduced with permission from Environmental Health Perspectives'

DOI: doi:10.1289/EHP175

Abstract

BACKGROUND: Epidemiological studies have provided strong evidence that fine particulate matter (PM2.5, aerodynamic diameter 2.5Ám and lower) can exacerbate asthmatic symptoms in children. Pro-oxidant components of PM2.5 are capable of directly generating reactive oxygen species. Oxidative burden is used to describe the capacity of PM2.5 to generate reactive oxygen species in the lung.

OBJECTIVE: This study investigated the association between airway inflammation in asthmatic children and oxidative burden of PM2.5 personal exposure.

METHODS: Daily PM2.5 personal exposure samples (n=249) of 62 asthmatic school-aged children in Montreal were collected over ten consecutive days. The oxidative burden of PM2.5 samples was determined in vitro as the depletion of low molecular weight antioxidants (ascorbate and glutathione) from a synthetic model of the fluid lining the respiratory tract. Airway inflammation was measured daily as fractional exhaled nitric oxide (FeNO).

RESULTS: A positive association was identified between FeNO and glutathione-related oxidative burden exposure in the previous 24 hours (6.0% increase per IQR change in glutathione). Glutathione-related oxidative burden was further found to be positively associated with FeNO over 1-day lag and 2-day lag periods. Results further demonstrate that corticosteroids use may reduce the FeNO response to elevated glutathione-related oxidative burden exposure (no use: 15.8%; irregular use: 3.8%), while mould (22.1%), dust (10.6%) or fur (13.1%) allergies may increase FeNO compared to children without these allergies (11.5%). No association was found between PM2.5 mass or ascorbate-related oxidative burden and FeNO levels.

CONCLUSIONS: Exposure to PM2.5 with elevated glutathione-related oxidative burden was associated with increased FeNO.

Item Details

Item Type:Refereed Article
Keywords:asthma, air quality, children
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Environmental and Occupational Health and Safety
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Environmental Health
Author:Wheeler, AJ (Dr Amanda Wheeler)
ID Code:110626
Year Published:2016
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-08-05
Last Modified:2017-11-06
Downloads:56 View Download Statistics

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