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Serotonin toxicity: Implications for clinical practice


Rotheram, A and Harris, W and Curtain, C and Nihil, D, Serotonin toxicity: Implications for clinical practice, Australasian Journal of Paramedicine, 13, (3) Article 5. ISSN 2202-7270 (2016) [Refereed Article]

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Introduction: Serotonin toxicity or serotonin syndrome is a potentially life threatening adverse reaction to the use of one or more serotonergic drugs. Patients presenting with low-level obscure symptoms may have pathophysiology rooted in adverse dopamine and serotonergic poly-pharmacy reactions involving illegal, over-the-counter and/or prescription drugs.

Aim: This paper presents an overview of serotonin toxicity, the criteria for diagnosing serotonin toxicity, and discusses management strategies.

Conclusion: Due to the increasing prevalence of serotonergic drugs, both legal and illicit, a high index of suspicion for serotonin toxicity across a broad patient demographic is recommended. We also recommend education and further research to both raise awareness and advance the clinical competence of health care providers.

Item Details

Item Type:Refereed Article
Keywords:serotonin toxicity, serotonin syndrome, selective serotonin reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, MDMA, ecstasy, adverse drug reactions, drug overdoses, diagnostic criteria, clinical practice, paramedicine
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Paramedicine
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Rotheram, A (Mr Auston Rotheram)
UTAS Author:Harris, W (Mr Wayne Harris)
UTAS Author:Curtain, C (Mr Colin Curtain)
ID Code:110529
Year Published:2016
Deposited By:Paramedicine
Deposited On:2016-08-01
Last Modified:2017-11-06

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