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Quantification of heterogeneity in lung disease with image-based pulmonary function testing

Citation

Stahr, CS and Samarage, CR and Donnelley, M and Farrow, N and Morgan, KS and Zosky, GR and Boucher, RC and Siu, KKW and Mall, MA and Parsons, DW and Dubsky, S and Fouras, A, Quantification of heterogeneity in lung disease with image-based pulmonary function testing, Scientific Reports, 6 Article 29438. ISSN 2045-2322 (2016) [Refereed Article]


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Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1038/srep29438

Abstract

Computed tomography (CT) and spirometry are the mainstays of clinical pulmonary assessment. Spirometry is effort dependent and only provides a single global measure that is insensitive for regional disease, and as such, poor for capturing the early onset of lung disease, especially patchy disease such as cystic fibrosis lung disease. CT sensitively measures change in structure associated with advanced lung disease. However, obstructions in the peripheral airways and early onset of lung stiffening are often difficult to detect. Furthermore, CT imaging poses a radiation risk, particularly for young children, and dose reduction tends to result in reduced resolution. Here, we apply a series of lung tissue motion analyses, to achieve regional pulmonary function assessment in β-ENaC-overexpressing mice, a well-established model of lung disease. The expiratory time constants of regional airflows in the segmented airway tree were quantified as a measure of regional lung function. Our results showed marked heterogeneous lung function in β-ENaC-Tg mice compared to wild-type littermate controls; identified locations of airway obstruction, and quantified regions of bimodal airway resistance demonstrating lung compensation. These results demonstrate the applicability of regional lung function derived from lung motion as an effective alternative respiratory diagnostic tool.

Item Details

Item Type:Refereed Article
Keywords:cystic fibrosis, CT imaging, heterogeneity
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Zosky, GR (Associate Professor Graeme Zosky)
ID Code:110492
Year Published:2016
Funding Support:National Health and Medical Research Council (1077905)
Web of Science® Times Cited:7
Deposited By:Medicine (Discipline)
Deposited On:2016-07-28
Last Modified:2018-03-07
Downloads:52 View Download Statistics

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