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Dimond, R and Patel, RP and Zaidi, STR, Fluoroquinolones, Drug Dosing in Obesity - Volume 1: Antimicrobials, Springer, STR Zaidi & JA Roberts (ed), Switzerland, pp. 45-52. ISBN 978-3-319-44034-7 (2016) [Research Book Chapter]

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Copyright 2016 Springer International Publishing Switzerland

DOI: doi:10.1007/978-3-319-44034-7_5


Fluoroquinolone antibiotics are frequently used in a variety of indications in hospital and outpatient settings due to the availability of oral dosage form. Pharmacokinetics of this particular class of antibiotics vary significantly among individual agents thus preventing a uniform approach to dose adjustment. Relatively more data is available for ciprofloxacin and levofloxacin compared to other agents in this class. This chapter outlines the available literature of pharmacokinetic changes in obese patients and recommend dosing for specific agents. Flouroquinolone antibiotics have significant dose related adverse effects and therefore, the clinical need of a flouroquinolone should be carefully considered before using them in obese patients who are likely to receive higher than the usually recommended doses.

Item Details

Item Type:Research Book Chapter
Keywords:ciprofloxacin, moxifloxacin, levofloxacin, dosing, adverse effects, obese
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Infectious diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Patel, RP (Dr Rahul Patel)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
ID Code:110368
Year Published:2016
Deposited By:Pharmacy
Deposited On:2016-07-25
Last Modified:2017-10-23

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