Significant physiological changes in obese patients limit the generalisability of dosing information of antimicrobials to this increasingly prevalent group of patients. Individualised approaches to drug dosing in obese patients are warranted to address the significant changes in the pharmacokinetics of antimicrobials in this patient group. Nevertheless, differences in the chemical, physiological and clinical characteristics of antimicrobials limit the application of established pharmacokinetics principle in obese patients. Important considerations while designing an antimicrobial regimen include, but not limited to an understanding of the focus of infection, relative susceptibilities of the micro-organism involved, the best match of the body size descriptor for the antimicrobial in question and the renal function of the patients under treatment.

Item Type:	Research Book Chapter
Keywords:	physiological changes, body-size descriptors, dosing, antimicrobials, pharmacokinetics, pharmacodynamics
Research Division:	Biomedical and Clinical Sciences
Research Group:	Clinical sciences
Research Field:	Infectious diseases
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	Zaidi, STR (Dr Tabish Razi Zaidi)
ID Code:	110362
Year Published:	2016
Deposited By:	Pharmacy
Deposited On:	2016-07-25
Last Modified:	2017-10-23
Downloads:	0