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Introduction
Citation
Zaidi, STR, Introduction, Drug Dosing in Obesity - Volume 1: Antimicrobials, Springer, STR Zaidi & JA Roberts (ed), Switzerland, pp. 1-12. ISBN 978-3-319-44034-7 (2016) [Research Book Chapter]
Copyright Statement
Copyright 2017 Springer International Publishing Switzerland
Official URL: http://www.springer.com/us/book/9783319440323
DOI: doi:10.1007/978-3-319-44034-7
Abstract
Significant physiological changes in obese patients limit the generalisability of dosing information of antimicrobials to this increasingly prevalent group of patients. Individualised approaches to drug dosing in obese patients are warranted to address the significant changes in the pharmacokinetics of antimicrobials in this patient group. Nevertheless, differences in the chemical, physiological and clinical characteristics of antimicrobials limit the application of established pharmacokinetics principle in obese patients. Important considerations while designing an antimicrobial regimen include, but not limited to an understanding of the focus of infection, relative susceptibilities of the micro-organism involved, the best match of the body size descriptor for the antimicrobial in question and the renal function of the patients under treatment.
Item Details
| Item Type: | Research Book Chapter |
|---|---|
| Keywords: | physiological changes, body-size descriptors, dosing, antimicrobials, pharmacokinetics, pharmacodynamics |
| Research Division: | Medical and Health Sciences |
| Research Group: | Clinical Sciences |
| Research Field: | Infectious Diseases |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Infectious Diseases |
| Author: | Zaidi, STR (Dr Tabish Razi Zaidi) |
| ID Code: | 110362 |
| Year Published: | 2016 |
| Deposited By: | Pharmacy |
| Deposited On: | 2016-07-25 |
| Last Modified: | 2017-10-23 |
| Downloads: | 0 |
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