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Introduction

Citation

Zaidi, STR, Introduction, Drug Dosing in Obesity - Volume 1: Antimicrobials, Springer, STR Zaidi & JA Roberts (ed), Switzerland, pp. 1-12. ISBN 978-3-319-44034-7 (2016) [Research Book Chapter]

Copyright Statement

Copyright 2017 Springer International Publishing Switzerland

Official URL: http://www.springer.com/us/book/9783319440323

DOI: doi:10.1007/978-3-319-44034-7

Abstract

Significant physiological changes in obese patients limit the generalisability of dosing information of antimicrobials to this increasingly prevalent group of patients. Individualised approaches to drug dosing in obese patients are warranted to address the significant changes in the pharmacokinetics of antimicrobials in this patient group. Nevertheless, differences in the chemical, physiological and clinical characteristics of antimicrobials limit the application of established pharmacokinetics principle in obese patients. Important considerations while designing an antimicrobial regimen include, but not limited to an understanding of the focus of infection, relative susceptibilities of the micro-organism involved, the best match of the body size descriptor for the antimicrobial in question and the renal function of the patients under treatment.

Item Details

Item Type:Research Book Chapter
Keywords:physiological changes, body-size descriptors, dosing, antimicrobials, pharmacokinetics, pharmacodynamics
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Infectious Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Zaidi, STR (Dr Tabish Razi Zaidi)
ID Code:110362
Year Published:2016
Deposited By:Pharmacy
Deposited On:2016-07-25
Last Modified:2017-10-23
Downloads:0

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