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Mild cognitive impairment predicts death and readmission within 30 days of discharge for heart failure


Huynh, QL and Negishi, K and Blizzard, L and Saito, M and De Pasquale, CG and Hare, JL and Leung, D and Stanton, T and Sanderson, K and Venn, AJ and Marwick, TH, Mild cognitive impairment predicts death and readmission within 30 days of discharge for heart failure, International Journal of Cardiology, 221 pp. 212-217. ISSN 0167-5273 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 Elsevier Ireland Ltd.

DOI: doi:10.1016/j.ijcard.2016.07.074


BACKGROUND: Cognitive impairment is highly prevalent in heart failure (HF), and may be associated with short-term readmission. This study investigated the role of cognition, incremental to other clinical and non-clinical factors, independent of depression and anxiety, in predicting 30-day readmission or death in HF.

METHODS: This study followed 565 patients from an Australia-wide HF longitudinal study. Cognitive function (MoCA score) together with standard clinical and non-clinical factors, mental health and 2D echocardiograms were collected before hospital discharge. The study outcomes were death and readmission within 30days of discharge. Logistic regression, Harrell's C-statistic, integrated discrimination improvement (IDI) and net reclassification index were used for analysis.

RESULTS: Among 565 patients, 255 (45%) had at least mild cognitive impairment (MoCA≤22). Death (n=43, 8%) and readmission (n=122, 21%) within 30days of discharge were more likely to occur among patients with mild cognitive impairment (OR=2.00, p=0.001). MoCA score was also negatively associated with 30-day readmission or death (OR=0.91, p<0.001) independent of other risk factors. Adding MoCA score to an existing prediction model of 30-day readmission significantly improved discrimination (C-statistic=0.715 vs. 0.617, IDI estimate 0.077, p<0.001). From prediction models developed from our study, adding MoCA score (C-statistic=0.83) provided incremental value to that of standard clinical and non-clinical factors (C-statistic=0.76) and echocardiogram parameters (C-statistic=0.81) in predicting 30-day readmission or death. Reclassification analysis suggests that addition of MoCA score improved classification for a net of 12% of patients with 30-day readmission or death and of 6% of patients without (p=0.002).

CONCLUSIONS: Mild cognitive impairment predicts short-term outcomes in HF, independent of clinical and non-clinical factors.

Item Details

Item Type:Refereed Article
Keywords:Cognitive function, Depression, Heart failure, Mortality, Rehospitalization
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Huynh, QL (Dr Quan Huynh)
UTAS Author:Negishi, K (Dr Kazuaki Negishi)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Saito, M (Dr Makoto Saito)
UTAS Author:Sanderson, K (Associate Professor Kristy Sanderson)
UTAS Author:Venn, AJ (Professor Alison Venn)
UTAS Author:Marwick, TH (Professor Tom Marwick)
ID Code:110217
Year Published:2016
Web of Science® Times Cited:54
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-07-20
Last Modified:2022-08-25

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