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Modulation of the synaptic drive to respiratory premotor and motor neurons


McCrimmon, DR and Zuperku, EJ and Hayashi, F and Dogas, Z and Hinrichsen, CFL and Stuth, EA and Tonkovic-Capin, M and Krolo, M and Hopp, FA, Modulation of the synaptic drive to respiratory premotor and motor neurons, Respiration Physiology, 110, (2-3) pp. 161-176. ISSN 0034-5687 (1997) [Refereed Article]

DOI: doi:10.1016/S0034-5687(97)00081-9


The characteristics of GABAergic inhibitory modulation of respiratory bulbospinal neuronal activity and short-term potentiation (STP) of phrenic motoneuronal activity were studied. Extracellular unit recording and picoejection techniques in anesthetized dogs showed that both the spontaneous rhythmic and reflexly induced discharge patterns of inspiratory (I) and expiratory (E) premotor neurons were proportionately amplified by the localized application of picomole amounts of bicuculline (Bic), a competitive GABA(A) antagonist. Intracellular recording and paired-pulse stimulation techniques in anesthetized rats demonstrated an STP of phrenic motor output that appears to be mediated by NMDA receptors and is associated with facilitation of EPSPs and prolonged depolarization of individual phrenic motoneurons. We speculate that both GABAergic gain modulation of premotor neuronal activity and NMDA-mediated STP of phrenic activity may be neural substrates which are involved with the optimization of respiratory and non- respiratory behaviors, via adaptive and/or differential control of breathing.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Hinrichsen, CFL (Dr Colin Hinrichsen)
ID Code:11017
Year Published:1997
Web of Science® Times Cited:73
Deposited By:Anatomy and Physiology
Deposited On:1997-08-01
Last Modified:2011-08-11

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