Kosmala, W and Przewlocka-Kosmala, M and Sharman, JE and Schultz, MG and Marwick, TH, Stability of left ventricular longitudinal and circumferential deformation over time and standard loading conditions, European Heart Journal - Cardiovascular Imaging pp. 1-7. ISSN 2047-2404 (2016) [Refereed Article]
Copyright 2016 The Author. Published on behalf of the European Society of Cardiology. All rights reserved.
METHODS AND RESULTS: Baseline and a 12-month follow-up 2D echocardiograms were performed in 191 Stage A heart failure patients with uncomplicated hypertension. These patients underwent simultaneous measurement of conventional and central blood pressures (BPs) and haemodynamic measurements by applanation tonometry. Significant, but weak correlations (r = 0.15-0.28) of LV strain parameters and their changes over the follow-up period were shown for the majority of LV afterload-associated variables, including central and brachial systolic, diastolic, and mean BPs; 24-h systolic and diastolic BPs; peak reservoir and excess pressures; central augmented pressure (CAP) and pulse pressure; augmentation index; and arterial elastance index (EaI). Central mean BP, EaI, and changes in CAP and EaI over follow-up were independent contributors to LV deformation in multivariable analysis. No improvement in the Bland-Altman 95% limits of agreement and correlation coefficients was seen with LV afterload correction of GLS and GCS using central BP indices.
CONCLUSIONS: LV longitudinal and circumferential strains in a population without apparent heart disease is relatively insusceptible to changes in LV afterload within physiological range, which, therefore, seem unlikely to be a significant confounder in repeated GLS or GCS observations.
|Item Type:||Refereed Article|
|Keywords:||left ventricular, loading conditions, strain (longitudinal, circumferential)|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Kosmala, W (Professor Wojciech Kosmala)|
|Author:||Sharman, JE (Professor James Sharman)|
|Author:||Schultz, MG (Dr Martin Schultz)|
|Author:||Marwick, TH (Professor Tom Marwick)|
|Deposited By:||Menzies Institute for Medical Research|
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