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Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags
Citation
Yousaf, F and Razi Zaidi, ST and Wanandy, Troy and Jose, MD and Patel, RP, Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags, Peritoneal Dialysis International, 36, (4) pp. 457-459. ISSN 0896-8608 (2016) [Contribution to Refereed Journal]
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DOI: doi:10.3747/pdi.2015.00169
Abstract
Intraperitoneal cefepime is used for the treatment of peritoneal
dialysis (PD)-associated peritonitis caused by gram-negative
bacteria. The current study investigated the stability of cefepime
in a pH-neutral PD solution. A reconstituted solution of cefepime
was injected into a total of 9 PD bags and stored at 4°C, 25°C or
37°C for various time points. Cefepime retained more than 90%
of its initial concentration for 168, 96, and 12 hours at 4°C, 25°C
and 37°C, respectively. No apparent physical precipitation or pH
change was observed during the study. This study provides crucial
information to healthcare professionals on the physical and chemical
stability of cefepime in the pH-neutral solution to help them in
preparing such admixtures in advance where required.
Item Details
Item Type: | Contribution to Refereed Journal |
---|---|
Keywords: | cefepime, HPLC, antibiotics, peritoneal dialysis |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Pharmacology and pharmaceutical sciences |
Research Field: | Pharmaceutical sciences |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Public health (excl. specific population health) not elsewhere classified |
UTAS Author: | Yousaf, F (Miss Farzana Yousaf) |
UTAS Author: | Razi Zaidi, ST (Dr Tabish Razi Zaidi) |
UTAS Author: | Wanandy, Troy (Mr Troy Wanandy) |
UTAS Author: | Jose, MD (Professor Matthew Jose) |
UTAS Author: | Patel, RP (Dr Rahul Patel) |
ID Code: | 110088 |
Year Published: | 2016 |
Web of Science® Times Cited: | 3 |
Deposited By: | Pharmacy |
Deposited On: | 2016-07-13 |
Last Modified: | 2016-07-18 |
Downloads: | 0 |
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