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Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags

journal contribution
posted on 2023-05-22, 02:49 authored by Yousaf, F, Syed Razi ZaidiSyed Razi Zaidi, Stephanus WanandyStephanus Wanandy, Matthew JoseMatthew Jose, Rahul PatelRahul Patel
Intraperitoneal cefepime is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by gram-negative bacteria. The current study investigated the stability of cefepime in a pH-neutral PD solution. A reconstituted solution of cefepime was injected into a total of 9 PD bags and stored at 4°C, 25°C or 37°C for various time points. Cefepime retained more than 90% of its initial concentration for 168, 96, and 12 hours at 4°C, 25°C and 37°C, respectively. No apparent physical precipitation or pH change was observed during the study. This study provides crucial information to healthcare professionals on the physical and chemical stability of cefepime in the pH-neutral solution to help them in preparing such admixtures in advance where required.

History

Publication title

Peritoneal Dialysis International

Volume

36

Issue

4

Pagination

457-459

ISSN

0896-8608

Department/School

School of Pharmacy and Pharmacology

Publisher

Multimed, Inc.

Place of publication

Canada

Repository Status

  • Restricted

Socio-economic Objectives

Public health (excl. specific population health) not elsewhere classified

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