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Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags

Citation

Yousaf, F and Razi Zaidi, ST and Wanandy, Troy and Jose, MD and Patel, RP, Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags, Peritoneal Dialysis International, 36, (4) pp. 457-459. ISSN 0896-8608 (2016) [Contribution to Refereed Journal]


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DOI: doi:10.3747/pdi.2015.00169

Abstract

Intraperitoneal cefepime is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by gram-negative bacteria. The current study investigated the stability of cefepime in a pH-neutral PD solution. A reconstituted solution of cefepime was injected into a total of 9 PD bags and stored at 4°C, 25°C or 37°C for various time points. Cefepime retained more than 90% of its initial concentration for 168, 96, and 12 hours at 4°C, 25°C and 37°C, respectively. No apparent physical precipitation or pH change was observed during the study. This study provides crucial information to healthcare professionals on the physical and chemical stability of cefepime in the pH-neutral solution to help them in preparing such admixtures in advance where required.

Item Details

Item Type:Contribution to Refereed Journal
Keywords:cefepime, HPLC, antibiotics, peritoneal dialysis
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Yousaf, F (Miss Farzana Yousaf)
UTAS Author:Razi Zaidi, ST (Dr Tabish Razi Zaidi)
UTAS Author:Wanandy, Troy (Mr Troy Wanandy)
UTAS Author:Jose, MD (Professor Matthew Jose)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:110088
Year Published:2016
Web of Science® Times Cited:3
Deposited By:Pharmacy
Deposited On:2016-07-13
Last Modified:2016-07-18
Downloads:0

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