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Intraperitoneal cefepime is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by gram-negative bacteria. The current study investigated the stability of cefepime in a pH-neutral PD solution. A reconstituted solution of cefepime was injected into a total of 9 PD bags and stored at 4°C, 25°C or 37°C for various time points. Cefepime retained more than 90% of its initial concentration for 168, 96, and 12 hours at 4°C, 25°C and 37°C, respectively. No apparent physical precipitation or pH change was observed during the study. This study provides crucial information to healthcare professionals on the physical and chemical stability of cefepime in the pH-neutral solution to help them in preparing such admixtures in advance where required.

Item Type:	Contribution to Refereed Journal
Keywords:	cefepime, HPLC, antibiotics, peritoneal dialysis
Research Division:	Biomedical and Clinical Sciences
Research Group:	Pharmacology and pharmaceutical sciences
Research Field:	Pharmaceutical sciences
Objective Division:	Health
Objective Group:	Public health (excl. specific population health)
Objective Field:	Public health (excl. specific population health) not elsewhere classified
UTAS Author:	Yousaf, F (Miss Farzana Yousaf)
UTAS Author:	Razi Zaidi, ST (Dr Tabish Razi Zaidi)
UTAS Author:	Wanandy, Troy (Mr Troy Wanandy)
UTAS Author:	Jose, MD (Professor Matthew Jose)
UTAS Author:	Patel, RP (Dr Rahul Patel)
ID Code:	110088
Year Published:	2016
Web of Science® Times Cited:	3
Deposited By:	Pharmacy
Deposited On:	2016-07-13
Last Modified:	2016-07-18
Downloads:	0