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Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags


Yousaf, F and Razi Zaidi, ST and Wanandy, Troy and Jose, MD and Patel, RP, Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags, Peritoneal Dialysis International, 36, (4) pp. 457-459. ISSN 0896-8608 (2016) [Contribution to Refereed Journal]

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DOI: doi:10.3747/pdi.2015.00169


Intraperitoneal cefepime is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by gram-negative bacteria. The current study investigated the stability of cefepime in a pH-neutral PD solution. A reconstituted solution of cefepime was injected into a total of 9 PD bags and stored at 4C, 25C or 37C for various time points. Cefepime retained more than 90% of its initial concentration for 168, 96, and 12 hours at 4C, 25C and 37C, respectively. No apparent physical precipitation or pH change was observed during the study. This study provides crucial information to healthcare professionals on the physical and chemical stability of cefepime in the pH-neutral solution to help them in preparing such admixtures in advance where required.

Item Details

Item Type:Contribution to Refereed Journal
Keywords:cefepime, HPLC, antibiotics, peritoneal dialysis
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Yousaf, F (Miss Farzana Yousaf)
UTAS Author:Razi Zaidi, ST (Dr Tabish Razi Zaidi)
UTAS Author:Wanandy, Troy (Mr Troy Wanandy)
UTAS Author:Jose, MD (Professor Matthew Jose)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:110088
Year Published:2016
Web of Science® Times Cited:3
Deposited By:Pharmacy
Deposited On:2016-07-13
Last Modified:2016-07-18

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