eCite Digital Repository

Connectivity of pathology: the olfactory system as a model for network-driven mechanisms of Alzheimer’s disease pathogenesis

Citation

Franks, K and Chuah, MI and King, AE and Vickers, JC, Connectivity of pathology: the olfactory system as a model for network-driven mechanisms of Alzheimer's disease pathogenesis, Frontiers in Aging Neuroscience, 7 Article 234. ISSN 1663-4365 (2015) [Refereed Article]


Preview
PDF
390Kb
  

Copyright Statement

Copyright 2015 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3389/fnagi.2015.00234

Abstract

The pathogenesis of Alzheimer’s disease (AD) has been postulated to preferentially impact specific neural networks in the brain. The olfactory system is a well-defined network that has been implicated in early stages of the disease, marked by impairment in olfaction and the presence of pathological hallmarks of the disease, even before clinical presentation. Discovering the cellular mechanisms involved in the connectivity of pathology will provide insight into potential targets for treatment. We review evidence from animal studies on sensory alteration through denervation or enrichment, which supports the notion of using the olfactory system to investigate the implications of connectivity and activity in the spread of pathology in AD.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer’s disease, olfaction, denervation, enrichment, connectivity, amyloid beta
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Franks, K (Miss Katherine Franks)
Author:Chuah, MI (Dr Inn Chuah)
Author:King, AE (Associate Professor Anna King)
Author:Vickers, JC (Professor James Vickers)
ID Code:109976
Year Published:2015
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2016-07-09
Last Modified:2016-08-23
Downloads:27 View Download Statistics

Repository Staff Only: item control page