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Connectivity of pathology: the olfactory system as a model for network-driven mechanisms of Alzheimer’s disease pathogenesis
Citation
Franks, K and Chuah, MI and King, AE and Vickers, JC, Connectivity of pathology: the olfactory system as a model for network-driven mechanisms of Alzheimer's disease pathogenesis, Frontiers in Aging Neuroscience, 7 Article 234. ISSN 1663-4365 (2015) [Refereed Article]
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Copyright Statement
Copyright 2015 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.3389/fnagi.2015.00234
Abstract
The pathogenesis of Alzheimer’s disease (AD) has been postulated to preferentially impact specific neural networks in the brain. The olfactory system is a well-defined network that has been implicated in early stages of the disease, marked by impairment in olfaction and the presence of pathological hallmarks of the disease, even before clinical presentation. Discovering the cellular mechanisms involved in the connectivity of pathology will provide insight into potential targets for treatment. We review evidence from animal studies on sensory alteration through denervation or enrichment, which supports the notion of using the olfactory system to investigate the implications of connectivity and activity in the spread of pathology in AD.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Alzheimer’s disease, olfaction, denervation, enrichment, connectivity, amyloid beta |
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Cellular Nervous System |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Franks, K (Miss Katherine Franks) |
| Author: | Chuah, MI (Dr Inn Chuah) |
| Author: | King, AE (Associate Professor Anna King) |
| Author: | Vickers, JC (Professor James Vickers) |
| ID Code: | 109976 |
| Year Published: | 2015 |
| Deposited By: | Wicking Dementia Research and Education Centre |
| Deposited On: | 2016-07-09 |
| Last Modified: | 2016-08-23 |
| Downloads: | 27 View Download Statistics |
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