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Synergetic and antagonistic effects of combined calcitriol and interferon-β treatment on cytokine production by stimulated PBMCs

Citation

Simpson JR, S and Stewart, N and van der Mei, I and Blizzard, L and Taylor, BV, Synergetic and antagonistic effects of combined calcitriol and interferon-β treatment on cytokine production by stimulated PBMCs, Journal of Neuroimmunology, 297 pp. 148-155. ISSN 0165-5728 (2016) [Refereed Article]

Copyright Statement

2016 Elsevier

DOI: doi:10.1016/j.jneuroim.2016.05.020

Abstract

Background: We evaluated the effects of calcitriol and interferon-β on in vitro PBMC cytokine production from a cohort of 22 healthy adults not on medication.

Methods: PBMCs were incubated with calcitriol and/or 100 or 400 IU interferon-β or nothing, followed by stimulation with concanavalin A.

Results: When combined, calcitriol and interferon-β appeared to potentiate the effects of one another on reducing IL-6. Calcitriol significantly reduced the production of IL-2, IL-4, IL-6, and IFN-γ, while interferon-β significantly reduced production of IL-6 and TNF-α, and increased IL-10.

Discussion: This is the first study to evaluate the effects of combined calcitriol and interferon-β on cytokine production in PBMCs in vitro, demonstrating novel synergetic effects.

Item Details

Item Type:Refereed Article
Keywords:Vitamin D, Interferon-β, IL-6, Cytokine, PBMC
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Simpson JR, S (Dr Steve Simpson JR)
Author:Stewart, N (Dr Niall Stewart)
Author:van der Mei, I (Associate Professor Ingrid van der Mei)
Author:Blizzard, L (Associate Professor Leigh Blizzard)
Author:Taylor, BV (Professor Bruce Taylor)
ID Code:109923
Year Published:2016
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-07-07
Last Modified:2017-02-20
Downloads:0

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