Simpson JR, S and Stewart, N and van der Mei, I and Blizzard, L and Taylor, BV, Synergetic and antagonistic effects of combined calcitriol and interferon-β treatment on cytokine production by stimulated PBMCs, Journal of Neuroimmunology, 297 pp. 148-155. ISSN 0165-5728 (2016) [Refereed Article]
© 2016 Elsevier
Methods: PBMCs were incubated with calcitriol and/or 100 or 400 IU interferon-β or nothing, followed by stimulation with concanavalin A.
Results: When combined, calcitriol and interferon-β appeared to potentiate the effects of one another on reducing IL-6. Calcitriol significantly reduced the production of IL-2, IL-4, IL-6, and IFN-γ, while interferon-β significantly reduced production of IL-6 and TNF-α, and increased IL-10.
Discussion: This is the first study to evaluate the effects of combined calcitriol and interferon-β on cytokine production in PBMCs in vitro, demonstrating novel synergetic effects.
|Item Type:||Refereed Article|
|Keywords:||Vitamin D, Interferon-β, IL-6, Cytokine, PBMC|
|Research Division:||Medical and Health Sciences|
|Research Field:||Central Nervous System|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Nervous System and Disorders|
|Author:||Simpson JR, S (Dr Steve Simpson JR)|
|Author:||Stewart, N (Dr Niall Stewart)|
|Author:||van der Mei, I (Associate Professor Ingrid van der Mei)|
|Author:||Blizzard, L (Professor Leigh Blizzard)|
|Author:||Taylor, BV (Professor Bruce Taylor)|
|Web of Science® Times Cited:||2|
|Deposited By:||Menzies Institute for Medical Research|
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