Background: We evaluated the effects of calcitriol and interferon-β on in vitro PBMC cytokine production from a cohort of 22 healthy adults not on medication.

Methods: PBMCs were incubated with calcitriol and/or 100 or 400 IU interferon-β or nothing, followed by stimulation with concanavalin A.

Results: When combined, calcitriol and interferon-β appeared to potentiate the effects of one another on reducing IL-6. Calcitriol significantly reduced the production of IL-2, IL-4, IL-6, and IFN-γ, while interferon-β significantly reduced production of IL-6 and TNF-α, and increased IL-10.

Discussion: This is the first study to evaluate the effects of combined calcitriol and interferon-β on cytokine production in PBMCs in vitro, demonstrating novel synergetic effects.

Item Type:	Refereed Article
Keywords:	Vitamin D, Interferon-β, IL-6, Cytokine, PBMC
Research Division:	Medical and Health Sciences
Research Group:	Neurosciences
Research Field:	Central Nervous System
Objective Division:	Health
Objective Group:	Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:	Nervous System and Disorders
Author:	Simpson JR, S (Dr Steve Simpson JR)
Author:	Stewart, N (Dr Niall Stewart)
Author:	van der Mei, I (Associate Professor Ingrid van der Mei)
Author:	Blizzard, L (Associate Professor Leigh Blizzard)
Author:	Taylor, BV (Professor Bruce Taylor)
ID Code:	109923
Year Published:	2016
Web of Science® Times Cited:	2
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2016-07-07
Last Modified:	2017-02-20
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