eCite Digital Repository
Synergetic and antagonistic effects of combined calcitriol and interferon-β treatment on cytokine production by stimulated PBMCs
Citation
Simpson JR, S and Stewart, N and van der Mei, I and Blizzard, L and Taylor, BV, Synergetic and antagonistic effects of combined calcitriol and interferon-β treatment on cytokine production by stimulated PBMCs, Journal of Neuroimmunology, 297 pp. 148-155. ISSN 0165-5728 (2016) [Refereed Article]
Copyright Statement
© 2016 Elsevier
DOI: doi:10.1016/j.jneuroim.2016.05.020
Abstract
Methods: PBMCs were incubated with calcitriol and/or 100 or 400 IU interferon-β or nothing, followed by stimulation with concanavalin A.
Results: When combined, calcitriol and interferon-β appeared to potentiate the effects of one another on reducing IL-6. Calcitriol significantly reduced the production of IL-2, IL-4, IL-6, and IFN-γ, while interferon-β significantly reduced production of IL-6 and TNF-α, and increased IL-10.
Discussion: This is the first study to evaluate the effects of combined calcitriol and interferon-β on cytokine production in PBMCs in vitro, demonstrating novel synergetic effects.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Vitamin D, Interferon-β, IL-6, Cytokine, PBMC |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Central nervous system |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Simpson JR, S (Dr Steve Simpson JR) |
UTAS Author: | Stewart, N (Dr Niall Stewart) |
UTAS Author: | van der Mei, I (Professor Ingrid van der Mei) |
UTAS Author: | Blizzard, L (Professor Leigh Blizzard) |
UTAS Author: | Taylor, BV (Professor Bruce Taylor) |
ID Code: | 109923 |
Year Published: | 2016 |
Web of Science® Times Cited: | 4 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2016-07-07 |
Last Modified: | 2018-12-14 |
Downloads: | 0 |
Repository Staff Only: item control page