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Trimetazidine attenuates the acute inflammatory response induced by Novolimus eluting bioresorbable coronary scaffold implantation

Citation

Amber, KI and Hadi, NR and Muhammad-Baqir, BM and Jamil, DA and Al-Aubaidy, HAM, Trimetazidine attenuates the acute inflammatory response induced by Novolimus eluting bioresorbable coronary scaffold implantation, International Journal of Cardiology, 220 pp. 514-519. ISSN 0167-5273 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 Elsevier Ireland Ltd.

DOI: doi:10.1016/j.ijcard.2016.06.172

Abstract

Methods: This was a randomized single blind study. Forty diabetic patients with critical coronary stenosis were subjected to elective coronary scaffold implantation in Al-Najaf Center for Cardiac Surgery and Trans-Catheter Therapy, Najaf, Iraq, between January and July 2015. All patients were informed about the nature of the study and they signed the consent form before they included in the study. Patients were randomly allocated into the two study groups: Group 1 included 20 patients who did the elective coronary scaffold implementation without trimetazidine medication. Group 2 included 20 patients who did the elective coronary scaffold implementation with a course of the trimetazidine (35 mg tablet/twice daily for 4 days).

Results: There were significant reduction in the levels of the interleukin-6 and cardiac troponin-I in the trimetazidine-treated group (group 2) compared to the control group (group 1) (P < 0.001), after 12 h and 24 h post-operative. This was associated with a significant rise in the levels of interleukin 10 in group 2 compared to group 1 (P < 0.001). Pentraxin-3 was significantly reduced in group 2 but only 24 h post-operative (P < 0.006).

Conclusion: Our study concluded that trimetazidine minimizes the acute inflammatory response occurred due to systemic release of inflammatory markers into blood in diabetic patients undergoing elective Novolimus bioresorbable coronary scaffold implementation.

Item Details

Item Type:Refereed Article
Keywords:Trimetazidine; Coronary artery disease; Percutaneous coronary intervention; Acute inflammation; Interleukin-6; Cardiac troponin-I; Interleukin-10; Pentraxin 3; C5a; Bioresorbable coronary scaffold.
Research Division:Medical and Health Sciences
Research Group:Medical Biochemistry and Metabolomics
Research Field:Medical Biochemistry: Carbohydrates
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Jamil, DA (Dr Dina Jamil)
Author:Al-Aubaidy, HAM (Dr Hayder Al-Aubaidy)
ID Code:109864
Year Published:2016
Deposited By:Medicine (Discipline)
Deposited On:2016-07-06
Last Modified:2016-08-23
Downloads:0

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