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Pandoraea pnomenusa isolated from an Australian patient with cystic fibrosis

Citation

Ambrose, M and Malley, RC and Warren, SJ and Beggs, SA and Swallow, OFE and McEwan, B and Stock, D and Roddam, LF, Pandoraea pnomenusa isolated from an Australian patient with cystic fibrosis, Frontiers in microbiology, 7 Article 692. ISSN 1664-302X (2016) [Refereed Article]


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Copyright 2016 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3389/fmicb.2016.00692

Abstract

Pandoraea species are considered as emerging pathogens in people with cystic fibrosis (CF). The contribution of these organisms to disease progression in CF patients is not fully understood owing in large measure to the scant reports in clinical and research literature describing their colonization of CF patients and their associated virulence determinants. In an effort to increase awareness and evidence for Pandoraea spp. infection in people with CF, and to stimulate research aimed at unraveling the pathogenic properties of Pandoraea, we report a case of a 26-year-old Australian (Tasmanian) man with CF who was chronically infected with Pandoraea pnomenusa for at least one year prior to his death from respiratory failure. In addition, we describe for the first time evidence suggesting that this bacterium is a facultative anaerobe and report on the availability of a whole genome sequence for this organism. To the best of our knowledge, this report represents only the second clinical case study of P. pnomenusa infection in the world, and the first in an Australian CF patient.

Item Details

Item Type:Refereed Article
Keywords:Pandoraea, cysticfibrosis, infection, anaerobe, lung
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Bacteriology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Ambrose, M (Dr Mark Ambrose)
Author:Malley, RC (Dr Roslyn Malley)
Author:Beggs, SA (Dr Sean Beggs)
Author:Swallow, OFE (Mr Oliver Swallow)
Author:Roddam, LF (Dr Louise Roddam)
ID Code:109640
Year Published:2016
Deposited By:Medicine (Discipline)
Deposited On:2016-06-24
Last Modified:2017-11-15
Downloads:56 View Download Statistics

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