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Front-to-back and dabbing wiping behaviour post-toilet associated with anal neoplasia and HR-HPV carriage in women with previous HPV-mediated gynaecological neoplasia
Citation
Simpson Jr, S and Blomfield, P and Cornall, A and Tabrizi, SN and Blizzard, L and Turner, R, Front-to-back and dabbing wiping behaviour post-toilet associated with anal neoplasia and HR-HPV carriage in women with previous HPV-mediated gynaecological neoplasia, Cancer Epidemiology, 42 pp. 124-132. ISSN 1877-7821 (2016) [Refereed Article]
Copyright Statement
Copyright 2016 Published by Elsevier Ltd.
DOI: doi:10.1016/j.canep.2016.04.001
Abstract
METHODS: Cross-sectional study of women with a previous HPV-mediated gynaecological neoplasia in Tasmania, Australia. Women presenting for follow-up gynaecological care had anal swab samples taken for anal cytology by Hologic Liquid ThinPrep, followed by HPV genotyping. Women with abnormal anal cytology were invited for high-resolution anoscopy. Potential risk factors, including post-toilet wiping behaviours, were queried by questionnaire while clinical covariates were extracted from medical records. Covariates of anal outcomes evaluated by log-binomial and log-multinomial regression.
RESULTS: From 163 women enrolled in the study, 65 (39.9%) had abnormal cytology, with 46 (28.2%) being high-grade. Of the 50 women with abnormal anal cytology having high-resolution anoscopy, 32 (64.0%) had abnormal histology with 13 (26.0%) being high-grade. Of the 123 women tested for HR-HPV DNA, 48 (39.0%) had HR-HPV detected, the most common genotypes being 16 and 51 (14/123, 11.4% for both). In addition to some known anal cancer risk factors, we found front-to-back wiping was associated with significantly increased (Prevalence ratio (PR) range: 1.99-3.60) prevalence of cytological and histological abnormality and HR-HPV carriage/co-carriage, while dabbing post-toilet was significantly associated with decreased prevalences (PR range: 0.50-0.62).
CONCLUSIONS: Post-toilet wiping behaviours were significantly associated with the prevalence of anal cytological, histological and HR-HPV carriage outcomes. This suggests a biologically plausible mechanism for HR-HPV introduction and the higher frequencies of anal neoplasia in women.
Item Details
Item Type: | Refereed Article |
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Keywords: | Anal neoplasia, Epidemiology, Human papillomavirus, Perineal hygiene, Post-toilet wiping, Women |
Research Division: | Health Sciences |
Research Group: | Epidemiology |
Research Field: | Epidemiology not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Simpson Jr, S (Dr Steve Simpson JR) |
UTAS Author: | Blomfield, P (Associate Professor Penelope Blomfield) |
UTAS Author: | Blizzard, L (Professor Leigh Blizzard) |
UTAS Author: | Turner, R (Professor Richard Turner) |
ID Code: | 109616 |
Year Published: | 2016 |
Web of Science® Times Cited: | 20 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2016-06-23 |
Last Modified: | 2018-12-06 |
Downloads: | 0 |
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