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Front-to-back and dabbing wiping behaviour post-toilet associated with anal neoplasia and HR-HPV carriage in women with previous HPV-mediated gynaecological neoplasia

Citation

Simpson Jr, S and Blomfield, P and Cornall, A and Tabrizi, SN and Blizzard, L and Turner, R, Front-to-back and dabbing wiping behaviour post-toilet associated with anal neoplasia and HR-HPV carriage in women with previous HPV-mediated gynaecological neoplasia, Cancer Epidemiology, 42 pp. 124-132. ISSN 1877-7821 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 Published by Elsevier Ltd.

DOI: doi:10.1016/j.canep.2016.04.001

Abstract

BACKGROUND: Anal cancer is a human papillomavirus (HPV)-mediated neoplasia of the anal squamous epithelium. Anal cancer is much more common among women, particularly those with a previous high-grade gynaecological neoplasia.

METHODS: Cross-sectional study of women with a previous HPV-mediated gynaecological neoplasia in Tasmania, Australia. Women presenting for follow-up gynaecological care had anal swab samples taken for anal cytology by Hologic Liquid ThinPrep, followed by HPV genotyping. Women with abnormal anal cytology were invited for high-resolution anoscopy. Potential risk factors, including post-toilet wiping behaviours, were queried by questionnaire while clinical covariates were extracted from medical records. Covariates of anal outcomes evaluated by log-binomial and log-multinomial regression.

RESULTS: From 163 women enrolled in the study, 65 (39.9%) had abnormal cytology, with 46 (28.2%) being high-grade. Of the 50 women with abnormal anal cytology having high-resolution anoscopy, 32 (64.0%) had abnormal histology with 13 (26.0%) being high-grade. Of the 123 women tested for HR-HPV DNA, 48 (39.0%) had HR-HPV detected, the most common genotypes being 16 and 51 (14/123, 11.4% for both). In addition to some known anal cancer risk factors, we found front-to-back wiping was associated with significantly increased (Prevalence ratio (PR) range: 1.99-3.60) prevalence of cytological and histological abnormality and HR-HPV carriage/co-carriage, while dabbing post-toilet was significantly associated with decreased prevalences (PR range: 0.50-0.62).

CONCLUSIONS: Post-toilet wiping behaviours were significantly associated with the prevalence of anal cytological, histological and HR-HPV carriage outcomes. This suggests a biologically plausible mechanism for HR-HPV introduction and the higher frequencies of anal neoplasia in women.

Item Details

Item Type:Refereed Article
Keywords:Anal neoplasia, Epidemiology, Human papillomavirus, Perineal hygiene, Post-toilet wiping, Women
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Simpson Jr, S (Dr Steve Simpson JR)
Author:Blomfield, P (Associate Professor Penelope Blomfield)
Author:Blizzard, L (Associate Professor Leigh Blizzard)
Author:Turner, R (Professor Richard Turner)
ID Code:109616
Year Published:2016
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-06-23
Last Modified:2017-12-05
Downloads:0

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