Wright, L and Dwyer, N and Power, J and Kritharides, L and Celermajer, D and Marwick, TH, Right Ventricular Systolic Function Responses to Acute and Chronic Pulmonary Hypertension: Assessment with Myocardial Deformation, Journal of the American Society of Echocardiography, 29, (3) pp. 259-266. ISSN 0894-7317 (2016) [Refereed Article]
Copyright 2016 American Society of Echocardiography
RESULTS: RV end-diastolic area, FAC, and RVFWS were significantly impaired in patients with PE (P < .001), with no significant differences in other clinical variables. In matched patients, receiver operating characteristic curve analysis revealed that RVFWS had significantly better discriminative power than the McConnell sign (P = .02), with a cutoff of -17.9%, sensitivity of 87.5%, specificity of 62.5%, and an area under the curve of 0.76. Sequential logistic regression demonstrated an incremental and independent benefit of using RVFWS to predict acute PE versus chronic PAH (P = .01). Observer concordance was superior for RVFWS compared with FAC (P < .01).
CONCLUSIONS: RVFWS is more predictive than RV end-diastolic area and less variable than FAC in distinguishing acute from chronic RV pressure overload. RVFWS adds incremental and independent information to standard measures of RV function in assessing the acuity of pulmonary hypertension.
|Item Type:||Refereed Article|
|Keywords:||Pulmonary embolism, Pulmonary hypertension, RV function, RV strain|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Wright, L (Ms Leah Wright)|
|Author:||Marwick, TH (Professor Tom Marwick)|
|Web of Science® Times Cited:||6|
|Deposited By:||Menzies Institute for Medical Research|
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