Subclinical left ventricular dysfunction has been associated with impaired exercise capacity in type 2 diabetes mellitus. In this community-based study of 274 asymptomatic T2DM patients (71±4years, 55% men) with preserved ejection fraction, a comprehensive resting echocardiogram was performed to gather sensitive systolic and diastolic function parameters (including speckle tracking echocardiography), and a standard six-minute walk test was performed. Tertiles of increasing waist circumference were associated with worsening walk distance. In this community-based study, we found an association of waist circumference with impaired exercise capacity, independent of age, gender, diabetes duration, insulin and angiotensin blockade, LV mass, systolic and diastolic function.

Item Type:	Refereed Article
Keywords:	Left ventricular dysfunction, Diabetes, Exercise capacity, Waist circumference, Six-minute walk test
Research Division:	Biomedical and Clinical Sciences
Research Group:	Cardiovascular medicine and haematology
Research Field:	Cardiology (incl. cardiovascular diseases)
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	Wang, Y (Ms Ying Wang)
UTAS Author:	Yang, H (Ms Hilda Yang)
UTAS Author:	Nolan, M (Mr Mark Nolan)
UTAS Author:	Negishi, K (Dr Kazuaki Negishi)
UTAS Author:	Burgess, J (Professor John Burgess)
UTAS Author:	Marwick, TH (Professor Tom Marwick)
ID Code:	109588
Year Published:	2016
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2016-06-22
Last Modified:	2022-08-30
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