109537 Journal Article.pdf (522.16 kB)
Brain Activation during Memory Encoding in Type 2 Diabetes Mellitus: A Discordant Twin Pair Study
journal contribution
posted on 2023-05-18, 20:07 authored by Wood, AG, Chen, J, Moran, C, Phan, T, Beare, R, Cooper, K, Litras, S, Srikanth, VType 2 diabetes mellitus increases the risk of dementia and neuronal dysfunction may occur years before perceptible cognitive decline. We aimed to study the impact of type 2 diabetes on brain activation during memory encoding in middle-aged people, controlling for age, sex, genes, and early-shared environment. Twenty-two twin pairs discordant for type 2 diabetes mellitus (mean age 60.9 years) without neurological disease were recruited from the Australian Twin Registry (ATR) and underwent functional magnetic resonance imaging (fMRI) during a memory encoding task, cognitive tests, and structural MRI. Type 2 diabetes was associated with significantly reduced activation in left hemisphere temporoparietal regions including angular gyrus, supramarginal gyrus, and middle temporal gyrus and significantly increased activation in bilateral posteriorly distributed regions. These findings were present in the absence of within-pair differences in standard cognitive test scores, brain volumes, or vascular lesion load. Differences in activation were more pronounced among monozygotic (MZ) pairs, with MZ individuals with diabetes also displaying greater frontal activation. These results provide evidence for preclinical memory-related neuronal dysfunction in type 2 diabetes. They support the search for modifiable later-life environmental factors or epigenetic mechanisms linking type 2 diabetes and cognitive decline.
History
Publication title
Journal of Diabetes ResearchArticle number
3978428Number
3978428Pagination
1-10ISSN
2314-6745Department/School
Menzies Institute for Medical ResearchPublisher
Hindawi Publishing CorporationPlace of publication
United StatesRights statement
Copyright 2016 Amanda G. Wood et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/Repository Status
- Open