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The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy


Moran, C and Tapp, RJ and Hughes, AD and Magnussen, CG and Blizzard, L and Phan, TG and Beare, R and Witt, N and Venn, A and Munch, G and Amaratunge, BC and Srikanth, V, The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy, Journal of Diabetes Research Article 6328953. ISSN 2314-6745 (2016) [Refereed Article]


Copyright Statement

Copyright 2016 C. Moran et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.1155/2016/6328953


It is uncertain whether small vessel disease underlies the relationship between Type 2 DiabetesMellitus (T2DM) and brain atrophy. We aimed to study whether retinal vascular architecture, as a proxy for cerebral small vessel disease, may modify or mediate the associations of T2DM with brain volumes. In this cross-sectional study using Magnetic Resonance Imaging (MRI) scans and retinal photographs in 451 people with and without T2DM, we measured brain volumes, geometric measures of retinal vascular architecture, clinical retinopathy, and MRI cerebrovascular lesions.Therewere 270 peoplewith (mean age 67.3 years) and 181without T2DM(mean age 72.9 years). T2DMwas associated with lower graymatter volume (𝑝 = 0.008). T2DMwas associated with greater arteriolar diameter (𝑝 = 0.03) and optimality ratio (𝑝 = 0.04), but these associations were attenuated by adjustments for age and sex. Only optimality ratio was associated with lower gray matter volume (𝑝 = 0.03). The inclusion of retinal measures in regression models did not attenuate the association of T2DM with gray matter volume. The association of T2DM with lower gray matter volume was independent of retinal vascular architecture and clinical retinopathy. Retinal vascular measures or retinopathy may not be sufficiently sensitive to confirm a microvascular basis for T2DM-related brain atrophy.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
ID Code:109523
Year Published:2016
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-06-21
Last Modified:2022-08-25
Downloads:172 View Download Statistics

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