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The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy
Citation
Moran, C and Tapp, RJ and Hughes, AD and Magnussen, CG and Blizzard, L and Phan, TG and Beare, R and Witt, N and Venn, A and Munch, G and Amaratunge, BC and Srikanth, V, The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy, Journal of Diabetes Research Article 6328953. ISSN 2314-6745 (2016) [Refereed Article]
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Copyright Statement
Copyright 2016 C. Moran et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Abstract
It is uncertain whether small vessel disease underlies the relationship between Type 2 DiabetesMellitus (T2DM) and brain atrophy.
We aimed to study whether retinal vascular architecture, as a proxy for cerebral small vessel disease, may modify or mediate
the associations of T2DM with brain volumes. In this cross-sectional study using Magnetic Resonance Imaging (MRI) scans and
retinal photographs in 451 people with and without T2DM, we measured brain volumes, geometric measures of retinal vascular
architecture, clinical retinopathy, and MRI cerebrovascular lesions.Therewere 270 peoplewith (mean age 67.3 years) and 181without
T2DM(mean age 72.9 years). T2DMwas associated with lower graymatter volume (𝑝 = 0.008). T2DMwas associated with greater
arteriolar diameter (𝑝 = 0.03) and optimality ratio (𝑝 = 0.04), but these associations were attenuated by adjustments for age and
sex. Only optimality ratio was associated with lower gray matter volume (𝑝 = 0.03). The inclusion of retinal measures in regression
models did not attenuate the association of T2DM with gray matter volume. The association of T2DM with lower gray matter
volume was independent of retinal vascular architecture and clinical retinopathy. Retinal vascular measures or retinopathy may
not be sufficiently sensitive to confirm a microvascular basis for T2DM-related brain atrophy.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurology and neuromuscular diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Magnussen, CG (Associate Professor Costan Magnussen) |
| UTAS Author: | Blizzard, L (Professor Leigh Blizzard) |
| UTAS Author: | Venn, A (Professor Alison Venn) |
| UTAS Author: | Srikanth, V (Dr Velandai Srikanth) |
| ID Code: | 109523 |
| Year Published: | 2016 |
| Web of Science® Times Cited: | 9 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2016-06-21 |
| Last Modified: | 2017-11-07 |
| Downloads: | 163 View Download Statistics |
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