Carey, LM and Crewther, S and Salvado, O and Linden, T and Connelly, A and Wilson, W and Howells, DW and Churilov, L and Ma, H and Tse, T and Rose, S and Palmer, S and Bougeat, P and Campbell, BC and Christensen, S and Macaulay, SL and Favaloro, J and O'Collins, V and McBride, S and Bates, S and Cowley, E and Dewey, H and Wijeratne, T and Gerraty, R and Phan, TG and Yan, B and Parsons, MW and Bladin, C and Barber, PA and Read, S and Wong, A and Lee, A and Kleinig, T and Hankey, GJ and Blacker, D and Markus, R and Leyden, J and Krause, M and Grimley, R and Mahant, N and Jannes, J and Sturn, J and Davis, SM and Donnan, GA, START Research Team, STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol, International journal of stroke : official journal of the International Stroke Society, 10, (4) pp. 636-44. ISSN 1747-4930 (2015) [Refereed Article]
RATIONALE: Stroke and poststroke depression are common and have a profound and ongoing impact on an individual's quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans.
AIMS: Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions.
DESIGN: In a longitudinal cohort study of 200 stroke survivors, the START-STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24 h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n = 100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified.
STUDY OUTCOMES: Clinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression.
|Item Type:||Refereed Article|
|Keywords:||cohort; cortical thickness; depression; functional neuroimaging; gene expression; stroke|
|Research Division:||Medical and Health Sciences|
|Research Field:||Central Nervous System|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Howells, DW (Professor David Howells)|
|Web of Science® Times Cited:||4|
|Deposited By:||Office of the School of Medicine|
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