Lalic, S and Jamsen, KM and Wimmer, BC and Tan, ECK and Hilmer, SN and Robson, L and Emery, T and Bell, JS, Polypharmacy and medication regimen complexity as factors associated with staff informant rated quality of life in residents of aged care facilities: a cross-sectional study, European Journal of Clinical Pharmacology ISSN 0031-6970 (2016) [Refereed Article]
Copyright 2016 Springer-Verlag Berlin Heidelberg
Purpose: The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs).
Methods: A cross-sectional study of 383 residents from six Australian RACFs was conducted. The primary exposures were polypharmacy (≥9 regular medications) and the validated Medication Regimen Complexity Index (MRCI). The outcome measure was staff informant rated quality of life assessed using the Quality of Life Alzheimer’s disease (QoL-AD) scale. Covariates included age, sex, Charlson’s comorbidity index, activities of daily living, and dementia severity. Logistic quantile regression was used to characterize the association between polypharmacy and QoL-AD (model 1) and MRCI and QoL-AD (model 2).
Results: The median age of the 383 residents was 88 years and 297 (78 %) residents were female. In total, 63 % of residents were exposed to polypharmacy and the median MRCI score (range) was 43.5 (4–113). After adjusting for the covariates, polypharmacy was not associated with either higher or lower QoL-AD scores (estimate −0.02; 95 % confidence interval (CI) −0.165, 0.124; p = 0.78). Similarly, after adjusting for the covariates, MRCI was not associated with either higher or lower QoL-AD scores (estimate −0.0009, 95 % CI −0.005, 0.003; p= 0.63).
Conclusions: These findings suggest that polypharmacy and medication regimen complexity are not associated with staff informant rated HRQoL. Further research is needed to investigate how specific medication classes may impact change in quality of life over time.
|Item Type:||Refereed Article|
|Keywords:||Medication regimen complexity; Nursing homes; Polypharmacy; Quality of life; Residential aged care|
|Research Division:||Medical and Health Sciences|
|Research Group:||Pharmacology and Pharmaceutical Sciences|
|Research Field:||Clinical Pharmacy and Pharmacy Practice|
|Objective Division:||Expanding Knowledge|
|Objective Group:||Expanding Knowledge|
|Objective Field:||Expanding Knowledge in the Medical and Health Sciences|
|Author:||Wimmer, BC (Dr Barbara Wimmer)|
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