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Childhood Psychosocial Factors and Coronary Artery Calcification in Adulthood: The Cardiovascular Risk in Young Finns Study


Juonala, M and Pulkki-Raback, L and Elovainio, M and Hakulinen, C and Magnussen, CG and Sabin, MA and Burgner, DP and Hare, DL and Hartiala, O and Ukkonen, H and Saraste, A and Kajander, S and Hutri-Kahonen, N and Kahonen, M and Rinta-Kiikka, I and Laitinen, T and Kainulainen, S and Viikari, JSA and Raitakari, OT, Childhood Psychosocial Factors and Coronary Artery Calcification in Adulthood: The Cardiovascular Risk in Young Finns Study, JAMA Pediatrics, 170, (5) pp. 466-472. ISSN 2168-6203 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 American Medical Association

DOI: doi:10.1001/jamapediatrics.2015.4121


IMPORTANCE: There is increasing evidence supporting the importance of psychosocial factors in the pathophysiology of atherosclerotic disease. They have been shown to be associated with the population attributable risk for myocardial infarction.

OBJECTIVE: To determine if a score of favorable childhood psychosocial factors would be associated with decreased coronary artery calcification in adulthood.

DESIGN, SETTING, AND PARTICIPANTS: The analyses were performed in 2015 using data gathered in 1980 and 2008 within the longitudinal Cardiovascular Risk in Young Finns Study. The data source consisted of 311 individuals who had psychosocial factors measured at ages 12 years to 18 years and coronary artery calcification measured 28 years later in adulthood. The summary measure of psychosocial factors in childhood comprised measures of socioeconomic factors, emotional factors, parental health behaviors, stressful events, self-regulation of the child, and social adjustment of the child.

MAIN OUTCOMES AND MEASURES: Coronary artery calcification at ages 40 years to 46 years.

RESULTS: Of the 311 participants, 48.2% were men. Of the participants, 55 (17.7%) had some calcium observed in their coronary arteries. A 1-SD increase in a favorable summary score of childhood psychological factors was associated with an adulthood coronary artery calcification probability of 0.85 (95% CI, 0.76-0.95) (P = .006). This inverse relationship remained significant after adjustment for age, sex, and conventional childhood risk factors (0.85; 95% CI, 0.74-0.97; P = .02) or for age, sex, adulthood conventional cardiovascular risk factors, socioeconomic status, social support, and depressive symptoms (0.83; 95% CI, 0.71-0.97; P = .02).

CONCLUSIONS AND RELEVANCE: In this longitudinal study, we observed an independent association between childhood psychosocial well-being and reduced coronary artery calcification in adulthood. A positive childhood psychosocial environment may decrease cardiovascular risk in adulthood and may represent a potentially modifiable risk determinant.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
ID Code:109327
Year Published:2016
Web of Science® Times Cited:24
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-06-08
Last Modified:2017-11-07

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