Throughout postnatal life oligodendrocyte progenitor cells proliferate and differentiate into mature myelinating oligodendrocytes in the central nervous system. Neuronal activity is a major external signal controlling this process. Neurotransmitters, or other signalling molecules released in response to neuronal activity, evoke transient increases in intracellular calcium in oligodendrocyte progenitor cells. As calcium can mediate cellular processes, including the transcription of genes involved in oligodendrocyte progenitor cell division and maturation, a rise in intracellular calcium may be a key signal translating changes in neuronal activity into changes in oligodendrocyte progenitor cell behaviour. Here we review recent advances in our understanding of how neuronal activity can evoke calcium signalling in oligodendrocyte progenitor cells.

Item Type:	Refereed Article
Keywords:	oligodendrocyte, myelin, calcium, neurotransmitter, activity-dependent myelination
Research Division:	Biomedical and Clinical Sciences
Research Group:	Neurosciences
Research Field:	Cellular nervous system
Objective Division:	Expanding Knowledge
Objective Group:	Expanding knowledge
Objective Field:	Expanding knowledge in the biological sciences
UTAS Author:	Pitman, KA (Dr Kimberley Pitman)
UTAS Author:	Young, KM (Professor Kaylene Young)
ID Code:	109309
Year Published:	2016
Funding Support:	National Health and Medical Research Council (1066025)
Web of Science® Times Cited:	12
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2016-06-08
Last Modified:	2022-08-23
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