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Activity-dependent calcium signalling in oligodendrocyte generation
journal contribution
posted on 2023-05-18, 19:50 authored by Kimberley PitmanKimberley Pitman, Kaylene YoungKaylene YoungThroughout postnatal life oligodendrocyte progenitor cells proliferate and differentiate into mature myelinating oligodendrocytes in the central nervous system. Neuronal activity is a major external signal controlling this process. Neurotransmitters, or other signalling molecules released in response to neuronal activity, evoke transient increases in intracellular calcium in oligodendrocyte progenitor cells. As calcium can mediate cellular processes, including the transcription of genes involved in oligodendrocyte progenitor cell division and maturation, a rise in intracellular calcium may be a key signal translating changes in neuronal activity into changes in oligodendrocyte progenitor cell behaviour. Here we review recent advances in our understanding of how neuronal activity can evoke calcium signalling in oligodendrocyte progenitor cells.
Funding
National Health & Medical Research Council
History
Publication title
International Journal of Biochemistry and Cell BiologyVolume
77Issue
Pt APagination
30-34ISSN
1357-2725Department/School
Menzies Institute for Medical ResearchPublisher
Pergamon-Elsevier Science LtdPlace of publication
The Boulevard, Langford Lane, Kidlington, Oxford, England, Ox5 1GbRights statement
Copyright 2016 Elsevier Ltd.Repository Status
- Restricted