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Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

Citation

Black, LJ and Burrows, S and Lucas, RM and Marshall, CE and Huang, R-C and Ping-Delfos, WCS and Beilin, LJ and Holt, PG and Hart, PH and Oddy, WH and Mori, TA, Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults, British Journal of Nutrition, 115, (11) pp. 1994-2002. ISSN 0007-1145 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 The Authors

DOI: doi:10.1017/S0007114516001185

Abstract

Evidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 736 (sd 282) and 754 (sd 259) nmol/l at 17 years and 700 (sd 242) and 743 (sd 262) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient -001; 95 % CI -003, -0003; P=0014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient -0002; 95 % CI -0003, -0001; P<0001) and positively associated with log-TAG in females (coefficient 0002; 95 % CI 00008, 0004; P=0003). These associations did not vary over time. There were no significant associations between serum 25(OH)D concentrations and HDL-cholesterol or SBP. Clinical trials in those with insufficient vitamin D status may be warranted to determine any beneficial effect of vitamin D supplementation on insulin resistance, while monitoring for any deleterious effect on TAG.

Item Details

Item Type:Refereed Article
Keywords:25-hydroxyvitamin D, vitamin D, cardiometabolic risks, adolescents
Research Division:Medical and Health Sciences
Research Group:Nutrition and Dietetics
Research Field:Clinical and Sports Nutrition
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Nutrition
Author:Oddy, WH (Professor Wendy Oddy)
ID Code:109099
Year Published:2016
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-05-24
Last Modified:2017-01-23
Downloads:0

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