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Neocentromeres

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posted on 2023-05-22, 16:53 authored by Owen MarshallOwen Marshall, Choo, KHA
Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs. © Springer Science+Business Media, LLC 2009. All rights reserved.

History

Publication title

The Kinetochore: From Molecular Discoveries to Cancer Therapy

Editors

P De Wulf and WC Earnshaw

Pagination

77-106

ISBN

978-1-4419-2398-1

Department/School

Menzies Institute for Medical Research

Publisher

Springer-Verlag New York

Place of publication

New York City

Extent

15

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the health sciences

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