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Neocentromeres

Citation

Marshall, OJ and Choo, KHA, Neocentromeres, The Kinetochore: From Molecular Discoveries to Cancer Therapy, Springer-Verlag New York, P De Wulf and WC Earnshaw (ed), New York City, pp. 77-106. ISBN 978-1-4419-2398-1 (2008) [Research Book Chapter]

DOI: doi:10.1007/978-0-387-69076-6

Abstract

Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs. © Springer Science+Business Media, LLC 2009. All rights reserved.

Item Details

Item Type:Research Book Chapter
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Biochemistry and Cell Biology not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Marshall, OJ (Dr Owen Marshall)
ID Code:109052
Year Published:2008
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-05-18
Last Modified:2016-05-18
Downloads:0

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