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Identification of an interaction between SOX9 and HSP70


Marshall, OJ and Harley, VR, Identification of an interaction between SOX9 and HSP70, F E B S Letters: (Federation of European Biochemical Societies), 496, (2-3) pp. 75-80. ISSN 0014-5793 (2001) [Refereed Article]

DOI: doi:10.1016/S0014-5793(01)02407-3


The campomelic dysplasia/autosomal sex reversal protein SOX9 is an important developmental transcription factor, required for correct bone and testis formation. Through in vitro and in vivo studies we have identified the heat shock protein HSP70 as an interacting partner for SOX9 in chondrocyte and testicular cell lines. HSP70 forms a ternary complex with DNA-bound SOX9. The interaction between HSP70 and SOX9 is ATP-independent and involves a highly conserved region of SOX9 hitherto of unknown function and the C-terminal region of HSP70. Our results implicate HSP70-SOX9 interactions in the assembly of multi-protein complexes during SOX9-mediated transcription.

Item Details

Item Type:Refereed Article
Keywords:Campomelic dysplasia, SOX9, HSP70, Protein-protein interaction
Research Division:Biological Sciences
Research Group:Biochemistry and cell biology
Research Field:Biochemistry and cell biology not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Marshall, OJ (Dr Owen Marshall)
ID Code:109046
Year Published:2001
Web of Science® Times Cited:25
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-05-18
Last Modified:2016-05-18

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