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Neocentromeres: new insights into centromere structure, disease development, and karyotype evolution

Citation

Marshall, OJ and Chueh, AC and Wong, LH and Choo, KHA, Neocentromeres: new insights into centromere structure, disease development, and karyotype evolution, American Journal of Human Genetics, 82, (2) pp. 261-282. ISSN 0002-9297 (2008) [Refereed Article]

DOI: doi:10.1016/j.ajhg.2007.11.009.

Abstract

Since the discovery of the first human neocentromere in 1993, these spontaneous, ectopic centromeres have been shown to be an astonishing example of epigenetic change within the genome. Recent research has focused on the role of neocentromeres in evolution and speciation, as well as in disease development and the understanding of the organization and epigenetic maintenance of the centromere. Here, we review recent progress in these areas of research and the significant insights gained.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Biochemistry and Cell Biology not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Marshall, OJ (Dr Owen Marshall)
ID Code:109036
Year Published:2008
Web of Science® Times Cited:202
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-05-18
Last Modified:2016-05-18
Downloads:0

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