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Neocentromeres: new insights into centromere structure, disease development, and karyotype evolution
journal contribution
posted on 2023-05-18, 19:33 authored by Owen MarshallOwen Marshall, Chueh, AC, Wong, LH, Choo, KHASince the discovery of the first human neocentromere in 1993, these spontaneous, ectopic centromeres have been shown to be an astonishing example of epigenetic change within the genome. Recent research has focused on the role of neocentromeres in evolution and speciation, as well as in disease development and the understanding of the organization and epigenetic maintenance of the centromere. Here, we review recent progress in these areas of research and the significant insights gained.
History
Publication title
American Journal of Human GeneticsVolume
82Pagination
261-282ISSN
0002-9297Department/School
Menzies Institute for Medical ResearchPublisher
Univ Chicago PressPlace of publication
1427 E 60Th St, Chicago, USA, Il, 60637-2954Repository Status
- Restricted