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Illuminating the role of cholinergic signaling in circuits of attention and emotionally salient behaviors

Citation

Luchicchi, A and Bloem, B and Viana, JNM and Mansvelder, HD and Role, LW, Illuminating the role of cholinergic signaling in circuits of attention and emotionally salient behaviors, Frontiers in Synaptic Neuroscience, 6 Article 24. ISSN 1663-3563 (2014) [Refereed Article]


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Copyright 2014 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3389/fnsyn.2014.00024

Abstract

Acetylcholine (ACh) signaling underlies specific aspects of cognitive functions and behaviors, including attention, learning, memory and motivation. Alterations in ACh signaling are involved in the pathophysiology of multiple neuropsychiatric disorders. In the central nervous system, ACh transmission is mainly guaranteed by dense innervation of select cortical and subcortical regions from disperse groups of cholinergic neurons within the basal forebrain (BF; e.g., diagonal band, medial septal, nucleus basalis) and the pontine-mesencephalic nuclei, respectively. Despite the fundamental role of cholinergic signaling in the CNS and the long standing knowledge of the organization of cholinergic circuitry, remarkably little is known about precisely how ACh release modulates cortical and subcortical neural activity and the behaviors these circuits subserve. Growing interest in cholinergic signaling in the CNS focuses on the mechanism(s) of action by which endogenously released ACh regulates cognitive functions, acting as a neuromodulator and/or as a direct transmitter via nicotinic and muscarinic receptors. The development of optogenetic techniques has provided a valuable toolbox with which we can address these questions, as it allows the selective manipulation of the excitability of cholinergic inputs to the diverse array of cholinergic target fields within cortical and subcortical domains. Here, we review recent papers that use the light-sensitive opsins in the cholinergic system to elucidate the role of ACh in circuits related to attention and emotionally salient behaviors. In particular, we highlight recent optogenetic studies which have tried to disentangle the precise role of ACh in the modulation of cortical-, hippocampal- and striatal-dependent functions.

Item Details

Item Type:Refereed Article
Keywords:acetylcholine, optogenetics, nicotinic receptors, limbic circuitries, attention
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Autonomic Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Viana, JNM (Mr Noel Viana)
ID Code:109015
Year Published:2014
Deposited By:Humanities
Deposited On:2016-05-17
Last Modified:2016-08-23
Downloads:22 View Download Statistics

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