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How arterial pressures affect the consideration of internal carotid artery angle as a risk factor for carotid artherosclerotic disease

Citation

Sinnott, MD and Cleary, PW and Harrison, SM and Cummins, SJ and Beare, R and Srikanth, V and Phan, TG, How arterial pressures affect the consideration of internal carotid artery angle as a risk factor for carotid artherosclerotic disease, Progress in Computational Fluid Dynamics, 15, (2) pp. 87-101. ISSN 1468-4349 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 Inderscience Enterprises Ltd.

DOI: doi:10.1504/PCFD.2015.068817

Abstract

Patient-specific geometric factors together with traditional risk factors may aid the early identification of patients at high risk of developing carotid artery disease requiring surgical intervention. Recent studies have linked aspects of carotid geometry to the pathogenesis of internal carotid artery (ICA) stenosis. Abnormal wall shear stress (WSS) is found for large ICA angles. Low WSS is believed to correspond to plaque formation whereas high WSS may result in plaque rupture and clotting. Here, the meshless method, smoothed particle hydrodynamics, is used to simulate Newtonian flow through a clinical, rigid walled, carotid bifurcation. The resulting flow field and WSS are reported for a range of different ICA angles. Varying the angle without changing boundary pressure conditions produces minimal change in flow and WSS. Greater ICA downstream pressures appear important for maintaining well-behaved flow through the bifurcation by suppressing flow separation downstream of the stenosis resulting in more uniform wall stress.

Item Details

Item Type:Refereed Article
Keywords:smoothed particle hydrodynamics, SPH, blood flow, stroke risk, wall shear stress, WSS, artherosclerosis, carotid artery disease, mesh-free numerical method
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Srikanth, V (Dr Velandai Srikanth)
ID Code:109009
Year Published:2015
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-05-17
Last Modified:2016-09-27
Downloads:0

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