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Are seaweed-derived fucoidans possible future anti-cancer agents?


Lowenthal, RM and Fitton, JH, Are seaweed-derived fucoidans possible future anti-cancer agents?, Journal of Phycology, 27, (5) pp. 2075-2077. ISSN 0022-3646 (2015) [Contribution to Refereed Journal]

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DOI: doi:10.1007/s10811-014-0444-x


Is there a role for brown macroalgae-derived fucoidan in cancer therapeutics? This review discusses the in vitro, in vivo and clinical data concerning fucoidan and cancer. Fucoidans vary according to the species from which they are derived, making direct comparisons between studies difficult. Data from in vitro studies indicate direct activity against some cancer cell lines. In vivo studies indicate cancer inhibitory activity, which may also be partly attributable to increases in innate and specific immunity. A small number of preliminary clinical studies indicate activity and should be followed up. Lastly, to date, there is no reported research into potential interactions between chemotherapy and fucoidan. Other naturally derived pharmaceuticals are known to interfere with certain forms of chemotherapy, and this should not be overlooked during the development of fucoidan.

Item Details

Item Type:Contribution to Refereed Journal
Keywords:fucan, chemotherapy, interaction, cell lines, clinical trial
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Oncology and carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Lowenthal, RM (Professor Ray Lowenthal)
ID Code:108934
Year Published:2015
Web of Science® Times Cited:22
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-05-12
Last Modified:2016-08-04

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