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Simulating and summarizing sources of gene tree incongruence


Woodhams, MD and Lockhart, PJ and Holland, BR, Simulating and summarizing sources of gene tree incongruence, Genome Biology and Evolution, 8, (5) pp. 1299-1315. ISSN 1759-6653 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.1093/gbe/evw065


We introduce a gene tree simulator that is designed for use in conjunction with approximate Bayesian computation approaches. We show that it can be used to determine the relative importance of hybrid speciation and introgression compared with incomplete lineage sorting (ILS) in producing patterns of incongruence across gene trees. Important features of the new simulator are (1) a choice of models to capture the decreasing probability of successful hybrid species formation or introgression as a function of genetic distance between potential parent species; (2) the ability for hybrid speciation to result in asymmetrical contributions of genetic material from each parent species; (3) the ability to vary the rates of hybrid speciation, introgression, and divergence speciation in different epochs; and (4) incorporation of the coalescent, so that patterns of incongruence due to ILS can be compared with those due to hybrid evolution. Given a set of gene trees generated by the simulator, we calculate a set of statistics, each measuring in a different way the discordance between the gene trees. We show that these statistics can be used to differentiate whether the gene tree discordance was largely due to hybridization, or only due to lineage sorting.

Item Details

Item Type:Refereed Article
Keywords:phylogenetic tree, simulator, hybridization, coalescence, incongruence, gene trees
Research Division:Mathematical Sciences
Research Group:Applied mathematics
Research Field:Biological mathematics
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the mathematical sciences
UTAS Author:Woodhams, MD (Dr Michael Woodhams)
UTAS Author:Holland, BR (Professor Barbara Holland)
ID Code:108926
Year Published:2016
Web of Science® Times Cited:4
Deposited By:Mathematics and Physics
Deposited On:2016-05-11
Last Modified:2017-11-01

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