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Study of Levodopa Response in Parkinson's disease: Observations on rates of motor progression


Ding, C and Ganesvaran, G and Alty, JE and Clissold, BG and McColl, CD and Reardon, KA and Schiff, M and Srikanth, V and Kempster, PA, Study of Levodopa Response in Parkinson's disease: Observations on rates of motor progression, Movement Disorders, 31, (4) pp. 589-592. ISSN 0885-3185 (2016) [Refereed Article]

Copyright Statement

2016 International Parkinson and Movement Disorder Society

DOI: doi:10.1002/mds.26497


INTRODUCTION: It is important to understand how the rate of motor progression in PD relates to dopaminergic treatment.

METHODS: The methods for this study comprised prospective defined off state measurements of the levodopa response at 3-year intervals over a mean 13.3-year period in 34 patients enrolled before treatment initiation.

RESULTS: Despite worsening of on and off scores, the magnitude of the l-dopa short-duration response is maintained as the disease progresses. A linear mixed-effects regression analysis of off phase motor scores showed a yearly deterioration of 2.3% of the maximum disability score. Greater motor disability at the commencement of treatment was an independent predictor of faster progression. Demented patients had worse motor function than those without dementia (P = 0.02), and motor deficit appeared to accelerate toward the end of the disease course in patients who had died.

CONCLUSIONS: These observations should inform clinical trial design for drugs with possible neuroprotective properties. 2016 International Parkinson and Movement Disorder Society.

Item Details

Item Type:Refereed Article
Keywords:Parkinson's disease, dementia, levodopa, natural history
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Srikanth, V (Dr Velandai Srikanth)
ID Code:108782
Year Published:2016
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-05-05
Last Modified:2017-11-06

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