eCite Digital Repository

Study of levodopa response in Parkinson's disease: observations on rates of motor progression


Ding, C and Ganesvaran, G and Alty, JE and Clissold, BG and McColl, CD and Reardon, KA and Schiff, M and Srikanth, V and Kempster, PA, Study of levodopa response in Parkinson's disease: observations on rates of motor progression, Movement Disorders, 31, (4) pp. 589-592. ISSN 0885-3185 (2016) [Refereed Article]

PDF (Post-print)

Copyright Statement

2016 International Parkinson and Movement Disorder Society

DOI: doi:10.1002/mds.26497


Introduction: It is important to understand how the rate of motor progression in PD relates to dopaminergic treatment.

Methods: The methods for this study comprised prospective defined off state measurements of the levodopa response at 3-year intervals over a mean 13.3-year period in 34 patients enrolled before treatment initiation.

Results: Despite worsening of on and off scores, the magnitude of the l-dopa short-duration response is maintained as the disease progresses. A linear mixed-effects regression analysis of off phase motor scores showed a yearly deterioration of 2.3% of the maximum disability score. Greater motor disability at the commencement of treatment was an independent predictor of faster progression. Demented patients had worse motor function than those without dementia (P = 0.02), and motor deficit appeared to accelerate toward the end of the disease course in patients who had died.

Conclusions: These observations should inform clinical trial design for drugs with possible neuroprotective properties.

Item Details

Item Type:Refereed Article
Keywords:Parkinson's disease, dementia, levodopa, natural history
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Alty, JE (Associate Professor Jane Alty)
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
ID Code:108782
Year Published:2016
Web of Science® Times Cited:8
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-05-05
Last Modified:2022-08-29
Downloads:16 View Download Statistics

Repository Staff Only: item control page