Ding, C and Ganesvaran, G and Alty, JE and Clissold, BG and McColl, CD and Reardon, KA and Schiff, M and Srikanth, V and Kempster, PA, Study of levodopa response in Parkinson's disease: observations on rates of motor progression, Movement Disorders, 31, (4) pp. 589-592. ISSN 0885-3185 (2016) [Refereed Article]
© 2016 International Parkinson and Movement Disorder Society
Methods: The methods for this study comprised prospective defined off state measurements of the levodopa response at 3-year intervals over a mean 13.3-year period in 34 patients enrolled before treatment initiation.
Results: Despite worsening of on and off scores, the magnitude of the l-dopa short-duration response is maintained as the disease progresses. A linear mixed-effects regression analysis of off phase motor scores showed a yearly deterioration of 2.3% of the maximum disability score. Greater motor disability at the commencement of treatment was an independent predictor of faster progression. Demented patients had worse motor function than those without dementia (P = 0.02), and motor deficit appeared to accelerate toward the end of the disease course in patients who had died.
Conclusions: These observations should inform clinical trial design for drugs with possible neuroprotective properties.
|Item Type:||Refereed Article|
|Keywords:||Parkinson's disease, dementia, levodopa, natural history|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Neurology and neuromuscular diseases|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Alty, JE (Dr Jane Alty)|
|UTAS Author:||Srikanth, V (Dr Velandai Srikanth)|
|Web of Science® Times Cited:||8|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||5 View Download Statistics|
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