Sanfilippo, PG and Huynh, E and Yazar, S and Hewitt, AW and Mackey, DA, Spectral-Domain Optical Coherence Tomography-Derived Characteristics of Bruch Membrane Opening in a Young Adult Australian Population, American Journal of Ophthalmology, 165 pp. 154-163. ISSN 0002-9394 (2016) [Refereed Article]
Copyright 2016 BY ELSEVIER INC. ALL RIGHTS RESERVED.
PURPOSE: To characterize and quantify Bruch membrane opening (BMO)-based optic nerve head (ONH) parameters in a large, young and healthy, predominantly white population.
DESIGN: Cross-sectional study and reliability analysis.
METHODS: The ONH of 1344 predominantly white subjects were imaged with spectral-domain optical coherence tomography (SD-OCT). A customized script, coded in Matlab, was used to manually segment and measure multiple BMO-based parameters of the ONH. Measurements were compared to those obtained with confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph; HRT). Regression analysis was performed to assess the relationship between BMO parameters and other ocular and demographic variables.
RESULTS: Mean BMO disc and neuroretinal rim (NRR) areas ranged from 0.94 to 4.06 mm2 (mean 1.77 ± 0.38 mm2) and 0.94 to 3.99 mm2 (mean 1.56 ± 0.31 mm2), respectively. When compared to the equivalent HRT measurements, SD-OCT-derived measures differed significantly for all comparable ONH parameters (P < .001). The limits of agreement computed from Bland-Altman plots comparing SD-OCT and HRT measurements showed suboptimal agreement between the techniques. Linear regression analysis demonstrated an effect of ethnicity, axial length, and refractive error on BMO-based parameters.
CONCLUSIONS: We have quantified BMO-based parameters in a large cohort of young adults using SD-OCT. These data will be informative in constructing normative profiles for clinical and research purposes in glaucoma diagnosis and management.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Ophthalmology and Optometry|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Hearing, Vision, Speech and Their Disorders|
|Author:||Hewitt, AW (Professor Alex Hewitt)|
|Author:||Mackey, DA (Professor David Mackey)|
|Web of Science® Times Cited:||4|
|Deposited By:||Menzies Institute for Medical Research|
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