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Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)
Citation
Grassmann, F and Cantsilieris, S and Schulz-Kuhnt, AS and White, SJ and Richardson, AJ and Hewitt, AW and Vote, BJ and Schmied, D and Guymer, RH and Weber, BH and Baird, PN, Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD), Journal of Neuroinflammation, 13 Article 81. ISSN 1742-2094 (2016) [Refereed Article]
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Copyright Statement
© 2016 Grassmann et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1186/s12974-016-0548-0
Abstract
METHODS: We used multiplex ligation-dependent probe amplification (MLPA) to determine the copy number of the C4 gene as well as of both relevant isoforms, C4A and C4B, and assessed their association with AMD using logistic regression models.
RESULTS: Here, we report on the analysis of 2645 individuals (1536 probands and 1109 unaffected controls), across three different centers, for multiallelic copy number variation (CNV) at the C4 locus. We find strong statistical significance for association of increased copy number of C4A (OR 0.81 (0.73; 0.89);P = 4.4 × 10(-5), with the effect most pronounced in individuals over 78 years (OR 0.67 (0.55; 0.81)) and females (OR 0.77 (0.68; 0.87)). Furthermore, this association is independent of known AMD-associated risk variants in the nearby CFB/C2 locus, particularly in females and in individuals over 78 years.
CONCLUSIONS: Our data strengthen the notion that complement dysregulation plays a crucial role in AMD etiology, an important finding for early intervention strategies and future therapeutics. In addition, for the first time, we provide evidence that multiallelic CNVs are associated with AMD pathology.
Item Details
Item Type: | Refereed Article |
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Keywords: | AMD, Age-related macular degeneration, C4, Complement, Copy number variation (CNV), Genetic association, Multiallelic |
Research Division: | Medical and Health Sciences |
Research Group: | Ophthalmology and Optometry |
Research Field: | Ophthalmology |
Objective Division: | Health |
Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
Objective Field: | Hearing, Vision, Speech and Their Disorders |
UTAS Author: | Hewitt, AW (Professor Alex Hewitt) |
UTAS Author: | Vote, BJ (Dr Brendan Vote) |
ID Code: | 108762 |
Year Published: | 2016 |
Web of Science® Times Cited: | 13 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2016-05-05 |
Last Modified: | 2017-11-06 |
Downloads: | 110 View Download Statistics |
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