Louise, S and Warrington, NM and McCaskie, PA and Oddy, WH and Zubrick, SR and Hands, B and Mori, TA and Briollais, L and Silburn, S and Palmer, LJ and Mattes, E and Beilin, LJ, Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study, Preventive Medicine, 54, (5) pp. 345-350. ISSN 0091-7435 (2012) [Refereed Article]
METHODS: Data from the Western Australian Pregnancy Cohort (Raine) Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used. Anxious-depressed scores (derived from the Childhood Behavior Checklist), body mass index (BMI) and blood pressure were measured at 5 (n=1681), 8 (n=1697), 10 (n=1575) and 14 (n=1386) years. At age 14 depressive symptom scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and insulin were also available. Cross sectional and longitudinal analyses were conducted.
RESULTS: At age 14, girls with higher anxious-depressed scores had higher BMI (p≤ 0.005) and homeostasis model assessment-estimated insulin resistance (p≤ 0.0001). This equated to a difference of 0.6 kg/m(2) and 0.3 units in predicted BMI and HOMA-IR respectively (top 5% vs. score of zero). Boys with higher anxious-depressed scores had lower systolic blood pressure trajectories (p=0.024).
CONCLUSION: Depressive scores appear to have differing influences on BMI, homeostasis model assessment-estimated insulin resistance and systolic blood pressure in boys and girls. Paradoxically boys with higher anxious-depressed scores had lower blood pressure throughout childhood.
|Item Type:||Refereed Article|
|Keywords:||Lifestyle, Depression, Cardiovascular disease, Risk factors, Child|
|Research Division:||Medical and Health Sciences|
|Research Group:||Nutrition and Dietetics|
|Research Field:||Clinical and Sports Nutrition|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Objective Field:||Preventive Medicine|
|Author:||Oddy, WH (Professor Wendy Oddy)|
|Web of Science® Times Cited:||7|
|Deposited By:||Menzies Institute for Medical Research|
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