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Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study

Citation

Louise, S and Warrington, NM and McCaskie, PA and Oddy, WH and Zubrick, SR and Hands, B and Mori, TA and Briollais, L and Silburn, S and Palmer, LJ and Mattes, E and Beilin, LJ, Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study, Preventive Medicine, 54, (5) pp. 345-350. ISSN 0091-7435 (2012) [Refereed Article]

DOI: doi:10.1016/j.ypmed.2012.03.004

Abstract

OBJECTIVE: To examine the influence of anxious/depressed scores on cardiovascular risk factors throughout childhood.

METHODS: Data from the Western Australian Pregnancy Cohort (Raine) Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used. Anxious-depressed scores (derived from the Childhood Behavior Checklist), body mass index (BMI) and blood pressure were measured at 5 (n=1681), 8 (n=1697), 10 (n=1575) and 14 (n=1386) years. At age 14 depressive symptom scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and insulin were also available. Cross sectional and longitudinal analyses were conducted.

RESULTS: At age 14, girls with higher anxious-depressed scores had higher BMI (p≤ 0.005) and homeostasis model assessment-estimated insulin resistance (p≤ 0.0001). This equated to a difference of 0.6 kg/m(2) and 0.3 units in predicted BMI and HOMA-IR respectively (top 5% vs. score of zero). Boys with higher anxious-depressed scores had lower systolic blood pressure trajectories (p=0.024).

CONCLUSION: Depressive scores appear to have differing influences on BMI, homeostasis model assessment-estimated insulin resistance and systolic blood pressure in boys and girls. Paradoxically boys with higher anxious-depressed scores had lower blood pressure throughout childhood.

Item Details

Item Type:Refereed Article
Keywords:Lifestyle, Depression, Cardiovascular disease, Risk factors, Child
Research Division:Medical and Health Sciences
Research Group:Nutrition and Dietetics
Research Field:Clinical and Sports Nutrition
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Preventive Medicine
Author:Oddy, WH (Professor Wendy Oddy)
ID Code:108590
Year Published:2012
Web of Science® Times Cited:7
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-04-26
Last Modified:2017-11-06
Downloads:0

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