Picone, DS and Schultz, MG and Climie, RED and Srikanth, V and Sharman, JE, Aortic-to-brachial stiffness gradient and kidney function in type 2 diabetes, Journal of Hypertension, 34, (6) pp. 1132-1139. ISSN 0263-6352 (2016) [Refereed Article]
Copyright 2016 Wolters Kluwer Health
METHODS: Study participants were 60 patients with T2DM and 60 age and sex-matched nondiabetic controls (58 ± 8 years, 55% male both). ab-SG was defined as the quotient of bPWV (carotid-to-radial) and aPWV (carotid-to-femoral) recorded via applanation tonometry. Kidney function was assessed using estimated glomerular filtration rate (eGFR). The exercise substudy was undertaken in 21 patients with T2DM and 21 matched nondiabetic controls during semirecumbent exercise.
RESULTS: ab-SG was significantly lower in patients with T2DM (0.99 ± 0.2 vs. 1.2 ± 0.3, P < 0.001) and aPWV, but not bPWV, was significantly higher (P < 0.001 and P = 0.25). A total of 58% of patients with T2DM vs. 27% of nondiabetic controls (χ2 = 11.0, P < 0.001) had a reversed ab-SG (aPWV ≥ bPWV). ab-SG predicted eGFR independent of age, sex, T2DM status, and cardiovascular risk factors (β = 13.2, P = 0.024), whereas aPWV did not (β = -0.88, P = 0.30). Exercise ab-SG was significantly lower in patients with T2DM (0.97 ± 0.2 vs. 1.2 ± 0.2, P < 0.001), but did not predict eGFR.
CONCLUSIONS: Patients with T2DM have a reversed ab-SG during rest and exercise. Resting ab-SG predicts kidney function independent of aPWV, implying a reversed ab-SG may have a pathophysiological function.
|Item Type:||Refereed Article|
|Keywords:||arterial stiffness, blood pressure, haemodynamics, kidney, renal insufficiency|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Picone, DS (Mr Dean Picone)|
|Author:||Schultz, MG (Dr Martin Schultz)|
|Author:||Climie, RED (Miss Rachel Climie)|
|Author:||Srikanth, V (Dr Velandai Srikanth)|
|Author:||Sharman, JE (Professor James Sharman)|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||1 View Download Statistics|
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