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Associations of blood pressure variability and retinal arteriolar diameter in participants with type 2 diabetes


Veloudi, P and Blizzard, L and Srikanth, VK and McCartney, P and Lukoshkova, EV and Hughes, AD and Head, GA and Sharman, JE, Associations of blood pressure variability and retinal arteriolar diameter in participants with type 2 diabetes, Diabetes and Vascular Disease Research, 13, (4) pp. 299-302. ISSN 1479-1641 (2016) [Refereed Article]

Copyright Statement

The Author(s) 2016

DOI: doi:10.1177/1479164116633424


Blood pressure variability is associated with macrovascular complications and stroke, but its association with the microcirculation in type II diabetes has not been assessed. This study aimed to determine the relationship between blood pressure variability indices and retinal arteriolar diameter in non-diabetic and type II diabetes participants. Digitized retinal images were analysed to quantify arteriolar diameters in 35 non-diabetic (aged 52  11 years; 49% male) and 28 type II diabetes (aged 61  9 years; 50% male) participants. Blood pressure variability was derived from 24-h ambulatory blood pressure. Arteriolar diameter was positively associated with daytime rate of systolic blood pressure variation (p = 0.04) among type II diabetes participants and negatively among non-diabetics (p = 0.008; interactionp = 0.001). This finding was maintained after adjusting for age, sex, body mass index and mean daytime systolic blood pressure. These findings suggest that the blood pressure variability-related mechanisms underlying retinal vascular disease may differ between people with and without type II diabetes.

Item Details

Item Type:Refereed Article
Keywords:Blood pressure variability, arteriolar diameter, diabetes, microcirculation
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Veloudi, P (Mrs Penny Veloudi)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Srikanth, VK (Dr Velandai Srikanth)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:108573
Year Published:2016
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-04-26
Last Modified:2017-11-03

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