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What's new in osteoarthritis pathogenesis?


Jones, G, What's new in osteoarthritis pathogenesis?, Internal Medicine Journal, 46, (2) pp. 229-236. ISSN 1444-0903 (2016) [Refereed Article]

Copyright Statement

2016 Royal Australasian College of Physicians

DOI: doi:10.1111/imj.12763


Osteoarthritis is the leading musculoskeletal cause of disability in the Western society. Despite this, it is still difficult to gain a precise definition of what osteoarthritis actually is. The methods used for the study are narrative review and viewpoint focussing on the knee. It is well known that there is a modest correlation between X-ray changes and pain. Improvements in imaging have shown that osteoarthritis should be regarded as an umbrella term for a number of pathophysiological processes leading to pain and/or cartilage loss. If these are inside the joint (such as bone marrow lesions, cartilage defects or meniscal tear) then they can be considered osteoarthritis, while those outside the joint (such as obesity, weak muscles and vitamin D deficiency) could be considered the osteoarthritis syndrome. These improvements in basic science are leading to lesion-specific therapies indicating the importance of trying to pinpoint causes of pain in the individual.

Item Details

Item Type:Refereed Article
Keywords:MRI, imaging, osteoarthritis, therapy
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:108483
Year Published:2016
Web of Science® Times Cited:17
Deposited By:Menzies Institute for Medical Research
Deposited On:2016-04-19
Last Modified:2017-11-01
Downloads:1 View Download Statistics

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